F38A1.8 SRP54-type proteins GTP-binding domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F38A1.8
Official Full Name: SRP54-type proteins GTP-binding domain-containing protein
Primary source: WormBase:WBGene00009521
Locus tag: CELE_F38A1.8
See related: AllianceGenome:WB:WBGene00009521
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activity and signal recognition particle binding activity. Predicted to be involved in protein targeting to ER. Predicted to be located in membrane. Predicted to be part of signal recognition particle receptor complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including enteric muscle; intestine; nervous system; pharynx; and reproductive system. Orthologous to human SRPRA (SRP receptor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See F38A1.8 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 9

Sequence:: Chromosome: IV; NC_003282.8 (1232825..1239852, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F38A1.8 (e-PCR)
- UniSTS:314252

Y104H12C.a (e-PCR)
- UniSTS:324027

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables signal recognition particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables signal recognition particle binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to ER	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of signal recognition particle receptor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SRP54-type proteins GTP-binding domain-containing protein

NP_741303.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

1232825..1239852 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171254.7 → NP_741303.2 SRP54-type proteins GTP-binding domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741303.2

Status: REVIEWED

UniProtKB/TrEMBL

A4F312, G4RYA5

Conserved Domains (4) summary

smart00963
Location:318 → 391

SRP54_N; SRP54-type protein, helical bundle domain

cd14826
Location:3 → 122

SR_alpha_SRX; SRX domain of signal recognition particle receptor subunit alpha

cd17876
Location:413 → 623

SRalpha_C; C-terminal domain of signal recognition particle receptor alpha subunit

pfam04086
Location:31 → 292

SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal