U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    bli-1 Cuticle collagen bli-1 [ Caenorhabditis elegans ]

    Gene ID: 174653, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    bli-1
    Official Full Name
    Cuticle collagen bli-1
    Primary source
    WormBase:WBGene00000251
    Locus tag
    CELE_C09G5.6
    See related
    AllianceGenome:WB:WBGene00000251
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Located in medial layer of collagen and cuticulin-based cuticle extracellular matrix. Is expressed in hyp7 syncytium and seam cell. Human ortholog(s) of this gene implicated in Stickler syndrome; multiple epiphyseal dysplasia 6; and osteochondrodysplasia. Orthologous to human COL9A1 (collagen type IX alpha 1 chain) and COL27A1 (collagen type XXVII alpha 1 chain). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See bli-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (10708960..10712156)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 Neighboring gene Cuticle collagen 39 Neighboring gene Putative cuticle collagen 80 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Immunocytochemical and freeze-fracture characterization of the Caenorhabditis elegans DR 847 bli-1(n361) mutant which produces abnormal cuticle blisters. de Melo JV, et al. Cell Tissue Res, 2003 May. PMID 12698356
    2. Ultrastructural analyses of the Caenorhabditis elegans DR 847 bli-1(n361) mutant which produces abnormal cuticle blisters. De Melo JV, et al. J Submicrosc Cytol Pathol, 2002 Jul. PMID 12408362
    3. The Caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol A and bisphenol S. Kucharíková S, et al. Toxicol Rep, 2023. PMID 36923443, Free PMC Article
    4. Dysregulation of let-7 by PEG modified graphene oxide in nematodes with deficit in epidermal barrier. Zhao L, et al. Ecotoxicol Environ Saf, 2019 Mar. PMID 30412893
    5. Chemotaxis by the nematode Caenorhabditis elegans: identification of attractants and analysis of the response by use of mutants. Ward S. Proc Natl Acad Sci U S A, 1973 Mar. PMID 4351805, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the abnormal cuticle blisters is due to an altered function of bli-1 gene, which is probably enzymatic
      Title: Immunocytochemical and freeze-fracture characterization of the Caenorhabditis elegans DR 847 bli-1(n361) mutant which produces abnormal cuticle blisters.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of collagen and cuticulin-based cuticle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen and cuticulin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in medial layer of collagen and cuticulin-based cuticle extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Cuticle collagen bli-1
    NP_496311.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10708960..10712156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063910.8 → NP_496311.2  Cuticle collagen bli-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496311.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09457
      Conserved Domains (3) summary
      pfam01391
      Location:426 → 483
      Collagen; Collagen triple helix repeat (20 copies)
      smart01088
      Location:20 → 58
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
      pfam08175
      Location:781 → 830
      SspO; Small acid-soluble spore protein O family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09457.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools