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    saeg-1 Suppressor of activated egl-4 protein 1 [ Caenorhabditis elegans ]

    Gene ID: 179505, updated on 9-Dec-2024

    Summary

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    Official Symbol
    saeg-1
    Official Full Name
    Suppressor of activated egl-4 protein 1
    Primary source
    WormBase:WBGene00010012
    Locus tag
    CELE_F53H10.2
    See related
    AllianceGenome:WB:WBGene00010012
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human MIDEAS (mitotic deacetylase associated SANT domain protein); TRERF1 (transcriptional regulating factor 1); and ZNF541 (zinc finger protein 541). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See saeg-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    15
    Sequence:
    Chromosome: V; NC_003283.11 (10852518..10865699, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Neurexin-3-beta Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene VWFA domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene ATPase_AAA_core domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex. Hao Y, et al. PLoS Genet, 2011 May. PMID 21573134, Free PMC Article
    2. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
    3. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Suppressor of activated egl-4 protein 1
    NP_001122952.1
    • Confirmed by transcript evidence
    NP_001122953.1
    • Confirmed by transcript evidence
    NP_001294697.1
    • Confirmed by transcript evidence
    NP_505769.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10852518..10865699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307768.4 → NP_001294697.1  Suppressor of activated egl-4 protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294697.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NTF3
      Conserved Domains (3) summary
      smart00717
      Location:322 → 365
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00096
      Location:493 → 515
      zf-C2H2; Zinc finger, C2H2 type
      cl21498
      Location:322 → 365
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    2. NM_073368.8 → NP_505769.2  Suppressor of activated egl-4 protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505769.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20733
      Conserved Domains (3) summary
      smart00717
      Location:565 → 608
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00096
      Location:736 → 758
      zf-C2H2; Zinc finger, C2H2 type
      cl21498
      Location:565 → 608
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    3. NM_001129480.4 → NP_001122952.1  Suppressor of activated egl-4 protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122952.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHS4
      Conserved Domains (3) summary
      smart00717
      Location:341 → 384
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00096
      Location:512 → 534
      zf-C2H2; Zinc finger, C2H2 type
      cl21498
      Location:341 → 384
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    4. NM_001129481.4 → NP_001122953.1  Suppressor of activated egl-4 protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122953.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHS5
      Conserved Domains (3) summary
      smart00717
      Location:245 → 288
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00096
      Location:416 → 438
      zf-C2H2; Zinc finger, C2H2 type
      cl21498
      Location:245 → 288
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20733.2

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