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    mrt-1 5' exonuclease Apollo [ Caenorhabditis elegans ]

    Gene ID: 172666, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mrt-1
    Official Full Name
    5' exonuclease Apollo
    Primary source
    WormBase:WBGene00045237
    Locus tag
    CELE_F39H2.5
    See related
    AllianceGenome:WB:WBGene00045237
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables 3'-5' exonuclease activity and single-stranded DNA binding activity. Involved in nucleotide-excision repair and telomere maintenance via telomerase. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in dyskeratosis congenita. Orthologous to human DCLRE1B (DNA cross-link repair 1B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mrt-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (8660831..8663105)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Peptidyl-prolyl cis-trans isomerase sig-7 Neighboring gene SPSAKWMRF-amide 3 Neighboring gene Synaptonemal complex protein 3 Neighboring gene Aminomethyltransferase folate-binding domain-containing protein Neighboring gene Nulp1-pending protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. Raices M, et al. Cell, 2008 Mar 7. PMID 18329362
    2. The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication. Boerckel J, et al. Genetics, 2007 May. PMID 17339221, Free PMC Article
    3. POT-3 preferentially binds the terminal DNA-repeat on the telomeric G-overhang. Yu X, et al. Nucleic Acids Res, 2023 Jan 25. PMID 36583365, Free PMC Article
    4. The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans. Meier B, et al. EMBO J, 2009 Nov 18. PMID 19779462, Free PMC Article
    5. The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1. Dietz S, et al. Nat Commun, 2021 May 11. PMID 33976151, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caenorhabditis elegans MRT-1 is a novel factor required for telomerase-mediated telomere replication and the DNA-damage response.
      Title: The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-3' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance via telomerase IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    5' exonuclease Apollo
    NP_740895.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8660831..8663105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170903.8 → NP_740895.1  5' exonuclease Apollo [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740895.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3E0
      Conserved Domains (3) summary
      cd04498
      Location:27 → 170
      hPOT1_OB2; hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ...
      pfam07522
      Location:476 → 515
      DRMBL; DNA repair metallo-beta-lactamase
      cl23716
      Location:212 → 371
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    Nucleotide Protein
    Heading Accession and Version

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