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    hbs-1 Tr-type G domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172672, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hbs-1
    Official Full Name
    Tr-type G domain-containing protein
    Primary source
    WormBase:WBGene00010622
    Locus tag
    CELE_K07A12.4
    See related
    AllianceGenome:WB:WBGene00010622
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in translation. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in beta thalassemia. Orthologous to human HBS1L (HBS1 like translational GTPase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hbs-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (8687634..8690937, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat-containing protein egg-6 Neighboring gene ncRNA Neighboring gene Homolog of Odr-2 (Two) Neighboring gene Small ribosomal subunit protein uS15m Neighboring gene MBD domain-containing protein;Pre-mRNA-splicing factor SLU7;Pre-mRNA-splicing factor SYF2 Neighboring gene putative ATP synthase subunit g 1, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitination of stalled ribosomes enables mRNA decay via HBS-1 and NONU-1 in vivo. Monem PC, et al. PLoS Genet, 2023 Jan. PMID 36626369, Free PMC Article
    2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tr-type G domain-containing protein
    NP_001021555.2
    • Confirmed by transcript evidence
    NP_001021556.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8687634..8690937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026384.6 → NP_001021555.2  Tr-type G domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021555.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P90922
      Conserved Domains (1) summary
      COG5256
      Location:176 → 606
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]

    2. NM_001026385.6 → NP_001021556.2  Tr-type G domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021556.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q564V6
      Conserved Domains (1) summary
      COG5256
      Location:158 → 588
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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