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    glct-1 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase [ Caenorhabditis elegans ]

    Gene ID: 188329, updated on 9-Dec-2024

    Summary

    Official Symbol
    glct-1
    Official Full Name
    Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
    Primary source
    WormBase:WBGene00011650
    Locus tag
    CELE_T09E11.1
    See related
    AllianceGenome:WB:WBGene00011650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Predicted to be involved in carbohydrate metabolic process and chondroitin sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in Barrett's esophagus and schizophrenia. Orthologous to human B3GAT1 (beta-1,3-glucuronyltransferase 1) and B3GAT2 (beta-1,3-glucuronyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See glct-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (12337968..12339239)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nuclear receptor domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Nuclear hormone receptor family member nhr-217 Neighboring gene pseudo

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
    NP_493121.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12337968..12339239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060720.2NP_493121.2  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493121.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02304, Q4VYA9
      Conserved Domains (1) summary
      pfam03360
      Location:60265
      Glyco_transf_43; Glycosyltransferase family 43