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    • Showing Current items.

    mkk-4 MAP kinase kinase mkk-4 [ Caenorhabditis elegans ]

    Gene ID: 185682, updated on 14-Nov-2024

    Summary

    Official Symbol
    mkk-4
    Official Full Name
    MAP kinase kinase mkk-4
    Primary source
    WormBase:WBGene00003368
    Locus tag
    CELE_F42G10.2
    See related
    AllianceGenome:WB:WBGene00003368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including p38MAPK cascade; positive regulation of axon extension involved in regeneration; and regulation of synaptic assembly at neuromuscular junction. Located in cytoplasm. Is expressed in head; hypodermis; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See mkk-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (10027856..10030130)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Peptidase_M13 domain-containing protein;Peptidase_M13_N domain-containing protein Neighboring gene ncRNA Neighboring gene Peptidase_M13 domain-containing protein Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene mitogen-activated protein kinase kinase Neighboring gene Fibronectin type-III domain-containing protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon regeneration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of axon extension involved in regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synapse organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    MAP kinase kinase mkk-4
    NP_509682.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10027856..10030130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077281.7NP_509682.1  MAP kinase kinase mkk-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509682.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01707, Q20347
      Conserved Domains (2) summary
      smart00220
      Location:72329
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06616
      Location:59347
      PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4