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    gcy-37 Soluble guanylate cyclase gcy-37 [ Caenorhabditis elegans ]

    Gene ID: 191658, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcy-37
    Official Full Name
    Soluble guanylate cyclase gcy-37
    Primary source
    WormBase:WBGene00001557
    Locus tag
    CELE_C54E4.3
    See related
    AllianceGenome:WB:WBGene00001557
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanylate cyclase activity. Predicted to be involved in cGMP-mediated signaling and response to oxygen levels. Predicted to be located in cytoplasm. Predicted to be part of guanylate cyclase complex, soluble. Is expressed in AQR; PQR; URXL; and URXR. Orthologous to human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcy-37 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    16
    Sequence:
    Chromosome: IV; NC_003282.8 (2150647..2159169, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Thyroglobulin type-1 domain-containing protein Neighboring gene Secreted protein Neighboring gene Inositol oxygenase Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Soluble guanylyl cyclases in Caenorhabditis elegans: NO is not the answer. Morton DB, et al. Curr Biol, 1999 Jul 29-Aug 12. PMID 10469574
    2. Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases. Zimmer M, et al. Neuron, 2009 Mar 26. PMID 19323996, Free PMC Article
    3. Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Gray JM, et al. Nature, 2004 Jul 15. PMID 15220933
    4. Soluble guanylate cyclases act in neurons exposed to the body fluid to promote C. elegans aggregation behavior. Cheung BH, et al. Curr Biol, 2004 Jun 22. PMID 15203005
    5. The Caenorhabditis elegans AHR-1 transcription complex controls expression of soluble guanylate cyclase genes in the URX neurons and regulates aggregation behavior. Qin H, et al. Dev Biol, 2006 Oct 15. PMID 16919260

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxygen levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Soluble guanylate cyclase gcy-37
    NP_500171.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2150647..2159169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067770.5 → NP_500171.2  Soluble guanylate cyclase gcy-37 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500171.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44468, Q65CM4, Q6DNF3
      Conserved Domains (4) summary
      smart00044
      Location:400 → 577
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam07700
      Location:3 → 165
      HNOB; Haem-NO-binding
      pfam07701
      Location:223 → 419
      HNOBA; Heme NO binding associated
      cl11967
      Location:425 → 609
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DNF3.1

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