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    lgc-41 Ligand-Gated ion Channel [ Caenorhabditis elegans ]

    Gene ID: 183331, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lgc-41
    Official Full Name
    Ligand-Gated ion Channel
    Primary source
    WormBase:WBGene00008022
    Locus tag
    CELE_C39B10.2
    See related
    AllianceGenome:WB:WBGene00008022
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in head neurons and nerve ring. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lgc-41 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    15
    Sequence:
    Chromosome: X; NC_003284.9 (10454260..10460506)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit BLS1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene putative transcription factor elt-4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronally produced betaine acts via a ligand-gated ion channel to control behavioral states. Hardege I, et al. Proc Natl Acad Sci U S A, 2022 Nov 29. PMID 36413500, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ligand-Gated ion Channel
    NP_001123116.1
    • Confirmed by transcript evidence
    NP_001359532.1
    • Confirmed by transcript evidence
    NP_001360682.1
    • Confirmed by transcript evidence
    NP_001360683.1
    • Confirmed by transcript evidence
    NP_001360684.1
    • Confirmed by transcript evidence
    NP_001360685.1
    • Confirmed by transcript evidence
    NP_001360686.1
    • Confirmed by transcript evidence
    NP_001360687.1
    • Confirmed by transcript evidence
    NP_001360688.1
    • Confirmed by transcript evidence
    NP_001360689.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10454260..10460506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373480.3 → NP_001360688.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IK97
      Conserved Domains (1) summary
      TIGR00860
      Location:41 → 491
      LIC; Cation transporter family protein

    2. NM_001373479.2 → NP_001360685.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IND2
      Conserved Domains (1) summary
      TIGR00860
      Location:41 → 511
      LIC; Cation transporter family protein

    3. NM_001373478.3 → NP_001360684.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKL0
      Conserved Domains (1) summary
      TIGR00860
      Location:41 → 514
      LIC; Cation transporter family protein

    4. NM_001373481.2 → NP_001360689.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IJ17
      Conserved Domains (1) summary
      TIGR00860
      Location:41 → 488
      LIC; Cation transporter family protein

    5. NM_001373475.2 → NP_001360682.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IK65
      Conserved Domains (1) summary
      TIGR00860
      Location:41 → 527
      LIC; Cation transporter family protein

    6. NM_001373474.1 → NP_001359532.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18518
      Conserved Domains (1) summary
      TIGR00860
      Location:41 → 530
      LIC; Cation transporter family protein

    7. NM_001129644.2 → NP_001123116.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7LPG1
      Conserved Domains (2) summary
      pfam02931
      Location:43 → 202
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:249 → 551
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    8. NM_001373473.2 → NP_001360683.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IK40
      Conserved Domains (3) summary
      TIGR00860
      Location:41 → 332
      LIC; Cation transporter family protein
      cd03559
      Location:530 → 554
      LGIC_TM; TM4 helix [structural motif]
      cl38911
      Location:527 → 557
      LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels

    9. NM_001373476.2 → NP_001360686.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IN65
      Conserved Domains (3) summary
      TIGR00860
      Location:41 → 332
      LIC; Cation transporter family protein
      cd03559
      Location:514 → 538
      LGIC_TM; TM4 helix [structural motif]
      cl38911
      Location:500 → 539
      LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels

    10. NM_001373477.1 → NP_001360687.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V6Z7Z1
      Conserved Domains (2) summary
      TIGR00860
      Location:41 → 332
      LIC; Cation transporter family protein
      pfam02932
      Location:249 → 534
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version

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