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    alh-13 Glutamate 5-kinase [ Caenorhabditis elegans ]

    Gene ID: 181417, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alh-13
    Official Full Name
    Glutamate 5-kinase
    Primary source
    WormBase:WBGene00011938
    Locus tag
    CELE_T22H6.2
    See related
    AllianceGenome:WB:WBGene00011938
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutamate-5-semialdehyde dehydrogenase activity. Predicted to be involved in L-proline biosynthetic process. Located in mitochondrion. Is expressed in intestine. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See alh-13 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (12782394..12787147)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-27 Neighboring gene Choline/ethanolaminephosphotransferase 1-like Neighboring gene Interleukin cytokine-related protein 17.1 Neighboring gene Seven TM Receptor Neighboring gene Seven TM Receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ethanol metabolism and osmolarity modify behavioral responses to ethanol in C. elegans. Alaimo JT, et al. Alcohol Clin Exp Res, 2012 Nov. PMID 22486589, Free PMC Article
    2. Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration. Wang C, et al. Proc Natl Acad Sci U S A, 2021 Aug 24. PMID 34413194, Free PMC Article
    3. Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans. Sawyer JM, et al. Genetics, 2011 Jul. PMID 21527776, Free PMC Article
    4. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Haynes CM, et al. Mol Cell, 2010 Feb 26. PMID 20188671, Free PMC Article
    5. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate-5-semialdehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate-5-semialdehyde dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Glutamate 5-kinase
    NP_510132.2
    • Confirmed by transcript evidence
    NP_510133.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      12782394..12787147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077731.7 → NP_510132.2  Glutamate 5-kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510132.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54889, Q9BI69
      Conserved Domains (3) summary
      TIGR01092
      Location:75 → 782
      P5CS; delta l-pyrroline-5-carboxylate synthetase
      cd07079
      Location:357 → 763
      ALDH_F18-19_ProA-GPR; Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19
      cd04256
      Location:74 → 346
      AAK_P5CS_ProBA; AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme ...

    2. NM_077732.9 → NP_510133.2  Glutamate 5-kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510133.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54889
      Conserved Domains (3) summary
      TIGR01092
      Location:73 → 780
      P5CS; delta l-pyrroline-5-carboxylate synthetase
      cd07079
      Location:355 → 761
      ALDH_F18-19_ProA-GPR; Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19
      cd04256
      Location:72 → 344
      AAK_P5CS_ProBA; AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54889.2

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