fntb-1 Protein farnesyltransferase subunit beta [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fntb-1
Official Full Name: Protein farnesyltransferase subunit beta
Primary source: WormBase:WBGene00006465
Locus tag: CELE_F23B12.6
See related: AllianceGenome:WB:WBGene00006465
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein prenyltransferase activity and zinc ion binding activity. Predicted to contribute to protein farnesyltransferase activity. Predicted to be involved in prenylation. Predicted to be part of protein farnesyltransferase complex. Is expressed in body wall musculature; neurons; pharyngeal muscle cell; rectal epithelial cell; and vulval cell. Human ortholog(s) of this gene implicated in anxiety disorder. Orthologous to human CHURC1-FNTB (CHURC1-FNTB readthrough) and FNTB (farnesyltransferase, CAAX box, subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fntb-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (14447651..14449587)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A genetic screen for mutants that display supernumerary neurites was performed to identify additional factors involved in this process. This screen identified mutations in fntb-1, the beta subunit of farnesyltransferase. The fntb-1 is expressed in neurons and acts cell-autonomously to regulate neurite formation.
Title: A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F23B12.5 (e-PCR)
- UniSTS:321397

F23B12.6 (e-PCR)
- UniSTS:309910

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to protein farnesyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein farnesyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in prenylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of protein farnesyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein farnesyltransferase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein farnesyltransferase subunit beta

NP_001379157.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

14447651..14449587

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392654.1 → NP_001379157.1 Protein farnesyltransferase subunit beta [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q19752

Conserved Domains (1) summary

cd02893
Location:63 → 358

FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...