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    cpr-1 Gut-specific cysteine proteinase [ Caenorhabditis elegans ]

    Gene ID: 179637, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpr-1
    Official Full Name
    Gut-specific cysteine proteinase
    Primary source
    WormBase:WBGene00000781
    Locus tag
    CELE_C52E4.1
    See related
    AllianceGenome:WB:WBGene00000781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in intestine and in male. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpr-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (11975551..11976756)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MIF-like protein mif-2 Neighboring gene putative small nuclear ribonucleoprotein Sm D2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gut-specific and developmental expression of a Caenorhabditis elegans cysteine protease gene. Ray C, et al. Mol Biochem Parasitol, 1992 Apr. PMID 1574082
    2. Regulation of the Caenorhabditis elegans gut cysteine protease gene cpr-1: requirement for GATA motifs. Britton C, et al. J Mol Biol, 1998. PMID 9761670
    3. Expression of Caenorhabditis elegans-expressed Trans-HPS, partial aminopeptidase H11 from Haemonchus contortus. Zhou QJ, et al. Exp Parasitol, 2014 Oct. PMID 25128369
    4. Identification of promoter elements of parasite nematode genes in transgenic Caenorhabditis elegans. Britton C, et al. Mol Biochem Parasitol, 1999 Oct 15. PMID 10551361
    5. Classes and crossreactivity of proteinases in the excretory-secretory products of Caenorhabditis elegans. Nic An Ultaigh S, et al. J Helminthol, 2007 Mar. PMID 17381874

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Gut-specific cysteine proteinase
    NP_506002.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11975551..11976756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073601.11 → NP_506002.2  Gut-specific cysteine proteinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506002.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25807, Q18783
      Conserved Domains (1) summary
      cd02620
      Location:86 → 325
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25807.2

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