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    ZK909.3 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [ Caenorhabditis elegans ]

    Gene ID: 191461, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZK909.3
    Official Full Name
    Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
    Primary source
    WormBase:WBGene00014148
    Locus tag
    CELE_ZK909.3
    See related
    AllianceGenome:WB:WBGene00014148
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. Orthologous to human HDDC3 (HD domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZK909.3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (14953490..14955492)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein;cAMP-dependent protein kinase catalytic subunit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box associated domain-containing protein Neighboring gene Transcription factor ces-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article
    2. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
    NP_493608.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14953490..14955492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061207.10 → NP_493608.2  Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493608.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18307
      Conserved Domains (1) summary
      COG0317
      Location:61 → 204
      SpoT; (p)ppGpp synthase/hydrolase, HD superfamily [Signal transduction mechanisms, Transcription]
    Nucleotide Protein
    Heading Accession and Version

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