src-2 Tyrosine protein-kinase src-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: src-2
Official Full Name: Tyrosine protein-kinase src-2
Primary source: WormBase:WBGene00005078
Locus tag: CELE_F49B2.5
See related: AllianceGenome:WB:WBGene00005078
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in nematode pharynx development. Predicted to be active in plasma membrane. Is expressed in anus; pharyngeal muscle cell; and vulva. Used to study Goldenhar syndrome. Orthologous to human FRK (fyn related Src family tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See src-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (14322237..14328965)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of KIN-22 induced morphological defects in the pharynx.These results suggest that SRC-1 and KIN-22 play distinct roles under the control of CSK-1.
Title: Distinct roles of the Src family kinases, SRC-1 and KIN-22, that are negatively regulated by CSK-1 in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F49B2.5 (e-PCR)
- UniSTS:319371

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode pharynx development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Tyrosine protein-kinase src-2

NP_493502.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14322237..14328965

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061101.5 → NP_493502.1 Tyrosine protein-kinase src-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493502.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45539

Conserved Domains (4) summary

cd10370
Location:120 → 215

SH2_Src_Src42; Src homology 2 (SH2) domain found in the Src oncogene at 42A (Src42)

cd11845
Location:61 → 112

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05068
Location:231 → 496

PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

pfam07714
Location:240 → 489

Pkinase_Tyr; Protein tyrosine kinase