kpc-1 Furin-like protease kpc-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: kpc-1
Official Full Name: Furin-like protease kpc-1
Primary source: WormBase:WBGene00002232
Locus tag: CELE_F11A6.1
See related: AllianceGenome:WB:WBGene00002232
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables serine-type endopeptidase activity and signaling receptor binding activity. Involved in several processes, including neuron development; positive regulation of cellular component organization; and protein processing. Located in neuronal cell body. Is expressed in several structures, including epithelial cell; intestine; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to several human genes including FURIN (furin, paired basic amino acid cleaving enzyme). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kpc-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (11675945..11680975)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We identify a Chimaerin (CHIN-1)- Furin (KPC-1) double-mutant that severely disrupts assembly. CHIN-1 and KPC-1 function noncanonically, in glia and pioneer neurons, for guidance-cue trafficking.
Title: Glia initiate brain assembly through noncanonical Chimaerin-Furin axon guidance in C. elegans.
The authors show that KPC-1, a Caenorhabditis elegans furin homolog, regulates the level of the branching receptor DMA-1 on dendrites by targeting it to late endosomes.
Title: Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions.
The C. elegans furin homolog KPC-1 is required for dauer IL2 dendritic arborization and dauer-specific nictation behavior. KPC-1 is also necessary for dendritic arborization of PVD and FLP sensory neurons.
Title: Dauer-specific dendrite arborization in C. elegans is regulated by KPC-1/Furin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F11A6.1 (e-PCR)
- UniSTS:318891

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite self-avoidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dendrite self-avoidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dauer entry	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide hormone processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to endosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendrite extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zymogen activation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Furin-like protease kpc-1

NP_492974.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

11675945..11680975

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060573.6 → NP_492974.2 Furin-like protease kpc-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492974.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O17797, O17798, Q17325

Conserved Domains (3) summary

cd04059
Location:174 → 470

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

pfam01483
Location:556 → 640

P_proprotein; Proprotein convertase P-domain

pfam16470
Location:61 → 139

S8_pro-domain; Peptidase S8 pro-domain