Efna2 ephrin A2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Efna2provided by MGI
Official Full Name: ephrin A2provided by MGI
Primary source: MGI:MGI:102707
See related: Ensembl:ENSMUSG00000003070 AllianceGenome:MGI:102707
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Elf1; Epl6; CEK7L; Eplg6; Lerk6
Summary: Enables ephrin receptor binding activity. Involved in bone remodeling; ephrin receptor signaling pathway; and osteoclast differentiation. Predicted to be located in neuromuscular junction and perikaryon. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and limb. Orthologous to human EFNA2 (ephrin A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 20.0), whole brain E14.5 (RPKM 18.4) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80015316..80025844)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (80179482..80190010)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Concurrent LI-rTMS induces changes in c-Fos expression but not behavior during a progressive ratio task with adult ephrin-A2A5(-/-) mice.
Title: Concurrent LI-rTMS induces changes in c-Fos expression but not behavior during a progressive ratio task with adult ephrin-A2A5(-/-) mice.
The loss of Ephrin-A2 and A5 ligands did not impact on the rate of wound closure or re-innervation after injury. However, changes in the gross morphology of the healed scar and in collagen histology of the scar dermis were observed in transgenic mice. Therefore Ephrin-A2 and A5 ligands may play an important role in final scar appearance associated with collagen deposition and structure.
Title: Ephrin-A2 affects wound healing and scarring in a murine model of excisional injury.
ephrin-A2 participates in the creation of excitatory neurons by inhibiting apical progenitor proliferation in the ventricular zone, with the disruption of ephrin-A2 signaling in these cells recapitulating the abnormal neocortex observed in the knockout.
Title: Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex.
Study showed that in comparison with wild-type mice revealed that ephrin-A2A5-/- mice had reduced accuracy and response rates, suggesting a goal-directed behavioral deficit, which was improved by low intensity repetitive transcranial magnetic stimulation.
Title: Online LI-rTMS during a Visual Learning Task: Differential Impacts on Visual Circuit and Behavioral Plasticity in Adult Ephrin-A2A5(-/-) Mice.
The ephrin-A2/-A3 DKO mice have utility as a novel ASD model with an emphasis on sensory abnormalities and restricted, repetitive behavioral symptoms.
Title: Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders.
The results of this study suggested that majority of the changes observed ephrin-A2 and ephrin-A5 KO mice appear to be mediated by the effects on motor neurons and their muscle targets, rather than changes in auditory sensitivity.
Title: The role of ephrin-A2 and ephrin-A5 in sensorimotor control and gating.
Ephrin-A2 and -A3 are negative regulators of the proliferative and neurogenic potentials of Muller cells.
Title: Ephrin-A2 and -A3 are negative regulators of the regenerative potential of Möller cells.
Ephrin-A2 and Ephrin-A5 are important for the functional development of cutaneous innervation.
Title: Ephrin-A2 and Ephrin-A5 are important for the functional development of cutaneous innervation in a mouse model.
At high frequencies, the ephrin-A2A5(-/-) mice exhibited thresholds that were significantly lower than in wild-type mice by approximately 20 dB, suggesting ephrin-A2 and ephrin-A5 may have frequency-specific effects on the auditory system.
Title: Auditory brainstem responses of ephrin-A2, ephrin-A5(-/-) and ephrin-A2A5(-/-) mice.
In EphA4 mutant mice, as well as after ephrin A2 knockdown using in utero electroporation, we found delayed interneuron migration at embryonic stages.
Title: EphA/ephrin A reverse signaling promotes the migration of cortical interneurons from the medial ganglionic eminence.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548473

Efna2 (e-PCR), detects polymorphism
- UniSTS:266979

Efna2 (e-PCR), detects polymorphism
- UniSTS:495860

Efna2 (e-PCR), detects polymorphism
- UniSTS:506875

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ephrin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in bone remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in bone remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in olfactory bulb development	IEA Inferred from Electronic Annotation more info
involved_in osteoclast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ephrin-A2

Names: CEK7-ligand; EPH related receptor tyrosine kinase ligand 6; ephrin A6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.