Tox thymocyte selection-associated high mobility group box [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Toxprovided by MGI
Official Full Name: thymocyte selection-associated high mobility group boxprovided by MGI
Primary source: MGI:MGI:2181659
See related: Ensembl:ENSMUSG00000041272 AllianceGenome:MGI:2181659
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700007F02Rik
Summary: Enables chromatin DNA binding activity. Involved in several processes, including alpha-beta T cell lineage commitment; cerebral cortex neuron differentiation; and regulation of positive thymic T cell selection. Acts upstream of or within hematopoietic or lymphoid organ development; lymphocyte differentiation; and positive regulation of natural killer cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human TOX (thymocyte selection associated high mobility group box). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in thymus adult (RPKM 22.1), whole brain E14.5 (RPKM 7.5) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A1; 4 3.04 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (6686353..6991557, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (6686353..6991557, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma.
Title: TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma.
Transcription factor TOX maintains the expression of Mst1 in controlling the early mouse NK cell development.
Title: Transcription factor TOX maintains the expression of Mst1 in controlling the early mouse NK cell development.
The Tox Gene Encodes Two Proteins with Distinct and Shared Roles in Gene Regulation.
Title: The Tox Gene Encodes Two Proteins with Distinct and Shared Roles in Gene Regulation.
Origin and fine-tuning of effector CD8 T cell subpopulations in chronic infection.
Title: Origin and fine-tuning of effector CD8 T cell subpopulations in chronic infection.
The VEGF-A induces the expression of transcription factor TOX in T cells to drive exhaustion-specific transcription program in T cells.
Title: VEGF-A drives TOX-dependent T cell exhaustion in anti-PD-1-resistant microsatellite stable colorectal cancers.
TOX is a critical factor for the normal progression of T cell dysfunction and the maintenance of exhausted T cells during chronic infection, and provide a link between the suppression of effector function intrinsic to CD8 T cells and protection against immunopathology
Title: TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.
hypothesis that TOX-induced exhaustion program serves to prevent the overstimulation of T cells and activation-induced cell death in settings of chronic antigen stimulation such as cancer
Title: TOX is a critical regulator of tumour-specific T cell differentiation.
identification of the HMG-box transcription factor TOX as a central regulator of Tex cells in mice
Title: TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion.
Results identify TOX as a transcriptional regulator of tissue-destructive CTLs in autoimmunity.
Title: Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8(+) T Cells.
is required for generation of a common innate lymphoid cell progenitor
Title: The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in CD4-positive, alpha-beta T cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in CD8-positive, alpha-beta T cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in NK T cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Peyer's patch development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebral cortex neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in leukocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lymph node development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in natural killer cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of positive thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: thymocyte selection-associated high mobility group box protein TOX

Names: thymocyte selection-associated HMG box; thymus high mobility group box protein TOX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001377078.1 → NP_001364007.1 thymocyte selection-associated high mobility group box protein TOX

Status: VALIDATED

Source sequence(s)

AL671871, AL831740

UniProtKB/Swiss-Prot

Q66JW3, Q8BKH9, Q8BYQ5, Q8R4H0

Conserved Domains (2) summary

COG5648
Location:257 → 360

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:261 → 310

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
NM_001377079.1 → NP_001364008.1 thymocyte selection-associated high mobility group box protein TOX

Status: VALIDATED

Source sequence(s)

AL671871, AL831740

UniProtKB/Swiss-Prot

Q66JW3, Q8BKH9, Q8BYQ5, Q8R4H0

Conserved Domains (2) summary

COG5648
Location:257 → 360

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:261 → 310

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
NM_145711.5 → NP_663757.3 thymocyte selection-associated high mobility group box protein TOX

See identical proteins and their annotated locations for NP_663757.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All 3 variants encode the same protein.

Source sequence(s)

AL671871, AL831740

Consensus CDS

CCDS17953.1

UniProtKB/Swiss-Prot

Q66JW3, Q8BKH9, Q8BYQ5, Q8R4H0

Related

ENSMUSP00000037966.4, ENSMUST00000039987.4

Conserved Domains (2) summary

COG5648
Location:257 → 360

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:261 → 310

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

6686353..6991557 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320230.2 → XP_017175719.1 thymocyte selection-associated high mobility group box protein TOX isoform X1

Conserved Domains (2) summary

COG5648
Location:218 → 321

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:222 → 271

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...