Dip2a disco interacting protein 2 homolog A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dip2aprovided by MGI
Official Full Name: disco interacting protein 2 homolog Aprovided by MGI
Primary source: MGI:MGI:2385920
See related: Ensembl:ENSMUSG00000020231 AllianceGenome:MGI:2385920
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dip2; mKIAA0184; Kiaa0184-hp; 4931420H10Rik
Summary: Enables acetate-CoA ligase activity. Involved in several processes, including dendritic spine morphogenesis; positive regulation of peptidyl-lysine acetylation; and regulation of modification of postsynaptic actin cytoskeleton. Located in dendritic spine and mitochondrion. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human DIP2A (disco interacting protein 2 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 15.1), colon adult (RPKM 14.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 38.76 cM

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (76098581..76181194, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (76263034..76345360, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dysregulation of AMPK-mTOR signaling leads to comorbid anxiety in Dip2a KO mice.
Title: Dysregulation of AMPK-mTOR signaling leads to comorbid anxiety in Dip2a KO mice.
A pilot study to investigate the alteration of gut microbial profile in Dip2a knockout mice.
Title: A pilot study to investigate the alteration of gut microbial profile in Dip2a knockout mice.
Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition.
Title: Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition.
DIP2A is involved in SOD-mediated antioxidative reactions in murine brain.
Title: DIP2A is involved in SOD-mediated antioxidative reactions in murine brain.
Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.
Title: Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.
Genome wide transcriptional analysis using wild type and Dip2a knockout mice in brain and lung at embryonic day 19.5 (E19.5) provided a genetic basis of molecular function of these genes.
Title: Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI426328 (e-PCR)
- UniSTS:164441

Dip2a (e-PCR), detects polymorphism
- UniSTS:546739

Dip2-pending (e-PCR), detects polymorphism
- UniSTS:259068

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-lysine acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: disco-interacting protein 2 homolog A

Names: DIP2 disco-interacting protein 2 homolog A; DIP2 homolog A

NP_001074888.2

EC 6.2.1.1

XP_006514002.1

EC 6.2.1.1

XP_006514003.1

EC 6.2.1.1

XP_006514004.1

EC 6.2.1.1

XP_030101068.1

EC 6.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081419.2 → NP_001074888.2 disco-interacting protein 2 homolog A

Status: VALIDATED

Source sequence(s)

AB093213, AI845124, AK050040, AK052899

Consensus CDS

CCDS35944.2

UniProtKB/TrEMBL

D3Z7D3, F8WI56

Related

ENSMUSP00000043710.8, ENSMUST00000036033.14

Conserved Domains (4) summary

COG0318
Location:321 → 914

CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]

pfam00501
Location:982 → 1456

AMP-binding; AMP-binding enzyme

pfam06464
Location:9 → 122

DMAP_binding; DMAP1-binding Domain

cl17068
Location:347 → 911

AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

76098581..76181194 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513941.5 → XP_006514004.1 disco-interacting protein 2 homolog A isoform X3

UniProtKB/TrEMBL

D3Z7D3

Conserved Domains (2) summary

cd05905
Location:918 → 1492

Dip2; Disco-interacting protein 2 (Dip2)

pfam06464
Location:10 → 122

DMAP_binding; DMAP1-binding Domain
XM_006513939.5 → XP_006514002.1 disco-interacting protein 2 homolog A isoform X1

UniProtKB/TrEMBL

D3Z7D3

Conserved Domains (2) summary

cd05905
Location:994 → 1568

Dip2; Disco-interacting protein 2 (Dip2)

pfam06464
Location:10 → 122

DMAP_binding; DMAP1-binding Domain
XM_006513940.5 → XP_006514003.1 disco-interacting protein 2 homolog A isoform X2

UniProtKB/Swiss-Prot

E0CXM7, Q8BWT5, Q8CHI0

Related

ENSMUSP00000125184.2, ENSMUST00000160048.8

Conserved Domains (2) summary

cd05905
Location:955 → 1529

Dip2; Disco-interacting protein 2 (Dip2)

pfam06464
Location:10 → 83

DMAP_binding; DMAP1-binding Domain
XM_030245208.2 → XP_030101068.1 disco-interacting protein 2 homolog A isoform X4

Conserved Domains (2) summary

pfam06464
Location:10 → 122

DMAP_binding; DMAP1-binding Domain

cl17068
Location:266 → 756

AFD_class_I; Adenylate forming domain, Class I superfamily