Itgb6 integrin beta 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgb6provided by MGI
Official Full Name: integrin beta 6provided by MGI
Primary source: MGI:MGI:96615
See related: Ensembl:ENSMUSG00000026971 AllianceGenome:MGI:96615
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2210409C20Rik; 4831415H04Rik
Summary: Enables integrin binding activity. Involved in cell adhesion mediated by integrin and transforming growth factor beta production. Acts upstream of or within several processes, including Langerhans cell differentiation; enamel mineralization; and lung development. Located in external side of plasma membrane. Part of integrin alphav-beta6 complex. Is expressed in several structures, including alimentary system; diaphragm; limb; metanephros; and vertebral axis musculature. Used to study asthma and pulmonary emphysema. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1H. Orthologous to human ITGB6 (integrin subunit beta 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 7.7), lung adult (RPKM 3.6) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.1- C1.2; 2 34.81 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (60428636..60553005, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (60598292..60722603, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of integrin alphavbeta6 protects against renal inflammation in chronic kidney disease by reduction of pro-inflammatory macrophages.
Title: Knockout of integrin αvβ6 protects against renal inflammation in chronic kidney disease by reduction of pro-inflammatory macrophages.
Integrin beta6 mediates epithelial-mesenchymal transition in diabetic kidney disease.
Title: Integrin β6 mediates epithelial-mesenchymal transition in diabetic kidney disease.
The ITGB6 gene: its role in experimental and clinical biology.
Title: The ITGB6 gene: its role in experimental and clinical biology.
alphavbeta6 integrin in junctional epithelium of the gingiva appears to positively regulate the expression of the AIM2 inflammasome and anti-inflammatory IL-10.
Title: Inflammasome and cytokine expression profiling in experimental periodontitis in the integrin β6 null mouse.
These data reveal a novel role for Elk1 regulating ITGB6 expression and highlight how dysregulation of Elk1 can contribute to human disease.
Title: Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression.
Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta.
Title: Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.
These data support the hypothesis that IL-1beta was initially induced by hyperoxia; alphavbeta6 subsequently interacted with and activated TGF-beta1.
Title: Interleukin-1β Promotes Epithelial-Derived Alveolar Elastogenesis via αvβ6 Integrin-Dependent TGF-β Activation.
alphaVbeta6 integrin-deficiency results in periodontal pathogens invading gingiva and aortic adventitia and eliciting inflammasome activation.
Title: Periodontal pathogens invade gingiva and aortic adventitia and elicit inflammasome activation in αvβ6 integrin-deficient mice.
the Wisp1-integrin beta6 pathway is inhibited by RGD peptides in septic mice, which protects against acute lung injury
Title: RGD peptides protects against acute lung injury in septic mice through Wisp1-integrin β6 pathway inhibition.
Data indicate that influenza A virus H1N1 increases collagen deposition, transforming growth factor beta (TGFbeta) activity, and levels of detectable alphavbeta6 integrin in lung.
Title: Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

D11Bir11 (e-PCR), detects polymorphism
- UniSTS:141709

D2Mit61 (e-PCR), detects polymorphism
- UniSTS:129456

D2Mit34 (e-PCR), detects polymorphism
- UniSTS:129233

Itgb6 (e-PCR), detects polymorphism
- UniSTS:507377

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular function activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Langerhans cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bronchiole development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within bronchiole development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to ionizing radiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within enamel mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_negative_effect gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hard palate development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within immune response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung alveolus development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phospholipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to virus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to wounding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within surfactant homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
part_of integrin alphav-beta6 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin alphav-beta6 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alphav-beta6 complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: integrin beta-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159564.2 → NP_001153036.1 integrin beta-6 precursor

See identical proteins and their annotated locations for NP_001153036.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.

Source sequence(s)

AL928546, AL928833, AL929012

Consensus CDS

CCDS16060.1

UniProtKB/Swiss-Prot

Q544J9, Q9Z0T9

UniProtKB/TrEMBL

B1AYG7

Related

ENSMUSP00000028348.3, ENSMUST00000028348.9

Conserved Domains (5) summary

smart00187
Location:30 → 454

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:624 → 705

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:730 → 773

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:456 → 485

I-EGF_1; Integrin beta epidermal growth factor like domain 1

NF033759
Location:467 → 646

exchanger_TraA; outer membrane exchange protein TraA
NM_021359.4 → NP_067334.1 integrin beta-6 precursor

See identical proteins and their annotated locations for NP_067334.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.

Source sequence(s)

AL928546, AL928833

Consensus CDS

CCDS16060.1

UniProtKB/Swiss-Prot

Q544J9, Q9Z0T9

UniProtKB/TrEMBL

B1AYG7

Related

ENSMUSP00000054944.9, ENSMUST00000059888.15

Conserved Domains (5) summary

smart00187
Location:30 → 454

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:624 → 705

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:730 → 773

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:456 → 485

I-EGF_1; Integrin beta epidermal growth factor like domain 1

NF033759
Location:467 → 646

exchanger_TraA; outer membrane exchange protein TraA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

60428636..60553005 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158669.1 → XP_036014562.1 integrin beta-6 isoform X1

UniProtKB/Swiss-Prot

Q544J9, Q9Z0T9

UniProtKB/TrEMBL

B1AYG7

Conserved Domains (5) summary

smart00187
Location:30 → 454

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:624 → 705

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:730 → 773

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:456 → 485

I-EGF_1; Integrin beta epidermal growth factor like domain 1

NF033759
Location:467 → 646

exchanger_TraA; outer membrane exchange protein TraA
XM_006498808.5 → XP_006498871.1 integrin beta-6 isoform X1

See identical proteins and their annotated locations for XP_006498871.1

UniProtKB/Swiss-Prot

Q544J9, Q9Z0T9

UniProtKB/TrEMBL

B1AYG7

Conserved Domains (5) summary

smart00187
Location:30 → 454

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:624 → 705

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:730 → 773

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:456 → 485

I-EGF_1; Integrin beta epidermal growth factor like domain 1

NF033759
Location:467 → 646

exchanger_TraA; outer membrane exchange protein TraA
XM_006498811.2 → XP_006498874.1 integrin beta-6 isoform X1

See identical proteins and their annotated locations for XP_006498874.1

UniProtKB/Swiss-Prot

Q544J9, Q9Z0T9

UniProtKB/TrEMBL

B1AYG7

Conserved Domains (5) summary

smart00187
Location:30 → 454

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:624 → 705

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:730 → 773

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:456 → 485

I-EGF_1; Integrin beta epidermal growth factor like domain 1

NF033759
Location:467 → 646

exchanger_TraA; outer membrane exchange protein TraA
XM_006498810.3 → XP_006498873.1 integrin beta-6 isoform X1

See identical proteins and their annotated locations for XP_006498873.1

UniProtKB/Swiss-Prot

Q544J9, Q9Z0T9

UniProtKB/TrEMBL

B1AYG7

Related

ENSMUSP00000117815.2, ENSMUST00000154764.2

Conserved Domains (5) summary

smart00187
Location:30 → 454

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:624 → 705

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:730 → 773

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:456 → 485

I-EGF_1; Integrin beta epidermal growth factor like domain 1

NF033759
Location:467 → 646

exchanger_TraA; outer membrane exchange protein TraA