Kif3a kinesin family member 3A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif3aprovided by MGI
Official Full Name: kinesin family member 3Aprovided by MGI
Primary source: MGI:MGI:107689
See related: Ensembl:ENSMUSG00000018395 AllianceGenome:MGI:107689
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kif3; Kifl; Kns3
Summary: Enables intraciliary transport particle B binding activity and microtubule binding activity. Involved in several processes, including alpha-tubulin acetylation; anterograde dendritic transport of neurotransmitter receptor complex; and microtubule cytoskeleton organization. Acts upstream of or within several processes, including chordate embryonic development; plasma membrane bounded cell projection organization; and regionalization. Located in centriole; motile cilium; and photoreceptor connecting cilium. Part of kinesin II complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including gonad; liver; nervous system; node; and spleen. Used to study dysostosis; polycystic kidney disease; and polycystic kidney disease 1. Orthologous to human KIF3A (kinesin family member 3A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 37.4), CNS E14 (RPKM 26.5) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 31.97 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (53456531..53495075)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (53565701..53604248)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis.
Title: Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis.
Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile.
Title: Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile.
Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.
Title: Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.
Photoreceptor Compartment-Specific TULP1 Interactomes.
Title: Photoreceptor Compartment-Specific TULP1 Interactomes.
KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step.
Title: KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step.
The mechanochemistry of the kinesin-2 KIF3AC heterodimer is related to strain-dependent kinetic properties of KIF3A and KIF3C.
Title: The mechanochemistry of the kinesin-2 KIF3AC heterodimer is related to strain-dependent kinetic properties of KIF3A and KIF3C.
Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk.
Title: Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk.
there may be a potential correlation between Pitchfork and Kif3a that could regulate primary cilia disassembly during palate development
Title: The correlative hypotheses between Pitchfork and Kif3a in palate development.
Study demonstrates that the non-canonical SMO/Gi/RHOA pathway functions outside primary cilia: Kif3a-deficient fibroblasts, unable to form primary cilia and to activate the canonical Hedgehog pathway, can activate RHOA robustly after stimulation of endogenous SMO with SHH or purmorphamine, and that KIF3A re-expression rescues ciliogenesis but does not affect RHOA activation.
Title: Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia.
KIF3A plays an important role in epithelium apoptosis and bronchial inflammation in asthma
Title: KIF3A knockdown sensitizes bronchial epithelia to apoptosis and aggravates airway inflammation in asthma.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (5) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236577

fb33b12.x1 (e-PCR)
- UniSTS:190403

AW124694 (e-PCR)
- UniSTS:180192

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables intraciliary transport particle B binding	IDA Inferred from Direct Assay more info	PubMed
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in alpha-tubulin acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde axonal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterograde dendritic transport	EXP Inferred from Experiment more info	PubMed
involved_in anterograde dendritic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in anterograde dendritic transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in anterograde dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IDA Inferred from Direct Assay more info	PubMed
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centriole-centriole cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dentate gyrus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral neural tube patterning	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral neural tube patterning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral neural tube patterning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epidermal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule anchoring at centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axo-dendritic protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of establishment or maintenance of cell polarity regulating cell shape	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell junction	ISO Inferred from Sequence Orthology more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon cytoplasm	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of kinesin II complex	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin II complex	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in photoreceptor connecting cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	EXP Inferred from Experiment more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynapse	NAS Non-traceable Author Statement more info	PubMed
located_in ribbon synapse	ISO Inferred from Sequence Orthology more info
colocalizes_with spindle microtubule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-like protein KIF3A

Names: N-4 kinesin; kinesin-II subunit; microtubule plus end-directed kinesin motor 3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290805.1 → NP_001277734.1 kinesin-like protein KIF3A isoform 2

See identical proteins and their annotated locations for NP_001277734.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AK053412, AK084748, AK147078, AK149180, AV356644, BB752635, BC052707, CJ157264

Consensus CDS

CCDS70185.1

UniProtKB/TrEMBL

Q3UI47

Related

ENSMUSP00000056197.9, ENSMUST00000057330.15

Conserved Domains (2) summary

cd01371
Location:13 → 345

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

pfam00225
Location:20 → 345

Kinesin; Kinesin motor domain
NM_001290806.1 → NP_001277735.1 kinesin-like protein KIF3A isoform 3

See identical proteins and their annotated locations for NP_001277735.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.

Source sequence(s)

AK053412, AK084748, AK149180, AK169425, AV356644, BB752635, BC052707, CJ157264

Consensus CDS

CCDS78947.1

UniProtKB/TrEMBL

Q3TET1

Related

ENSMUSP00000133432.2, ENSMUST00000173744.8

Conserved Domains (2) summary

cd01371
Location:13 → 345

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

pfam00225
Location:20 → 345

Kinesin; Kinesin motor domain
NM_008443.4 → NP_032469.2 kinesin-like protein KIF3A isoform 1

See identical proteins and their annotated locations for NP_032469.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK053412, AK084748, AK149180, AV356644, BB752635, BC052707, CJ157264

Consensus CDS

CCDS48795.1

UniProtKB/Swiss-Prot

P28741, Q7TSZ7

Related

ENSMUSP00000112782.3, ENSMUST00000120613.9

Conserved Domains (2) summary

cd01371
Location:13 → 345

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

pfam00225
Location:20 → 345

Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

53456531..53495075

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532325.5 → XP_006532388.1 kinesin-like protein KIF3A isoform X1

UniProtKB/TrEMBL

B1AQZ2

Related

ENSMUSP00000113848.3, ENSMUST00000118353.9

Conserved Domains (3) summary

TIGR02168
Location:449 → 615

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01371
Location:13 → 345

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

pfam02463
Location:340 → 717

SMC_N; RecF/RecN/SMC N terminal domain
XM_006532328.5 → XP_006532391.1 kinesin-like protein KIF3A isoform X3

Conserved Domains (2) summary

COG1196
Location:360 → 586

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01371
Location:13 → 345

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
XM_006532326.5 → XP_006532389.1 kinesin-like protein KIF3A isoform X2

Conserved Domains (2) summary

COG1196
Location:340 → 611

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01371
Location:13 → 345

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
XM_036156358.1 → XP_036012251.1 kinesin-like protein KIF3A isoform X4

Conserved Domains (2) summary

COG0419
Location:336 → 564

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd01371
Location:13 → 345

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins