H1f9 H1.9 linker histone [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H1f9provided by MGI
Official Full Name: H1.9 linker histoneprovided by MGI
Primary source: MGI:MGI:2136691
See related: Ensembl:ENSMUSG00000038994 AllianceGenome:MGI:2136691
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H1-9; H1.9; Hils1; TISP64
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is expressed in nuclei of late maturing spermatids. [provided by RefSeq, Nov 2015]
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Genomic context

Location:: 11 D; 11 59.01 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (94858419..94859282)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (94967593..94968456)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hils1 may play an important role in the structural changes of spermatid nuclei, such as nuclear condensation, and gene regulation of haploid germ cell differentiation.
Title: Isolation and characterization of a novel cDNA encoding a DNA-binding protein (Hils1) specifically expressed in testicular haploid germ cells.
HILS1 is implicated in chromatin remodeling during mammalian spermiogenesis.
Title: HILS1 is a spermatid-specific linker histone H1-like protein implicated in chromatin remodeling during mammalian spermiogenesis.
318-base pair (bp) 5'-proximal region, corresponding to first 70-bp proximal TATA-less promoter, and 248 bp of 5'-untranslated region is sufficient to confer testis- and spermatid-specific transcription and posttranscriptional control of mouse hils1 gene.
Title: Control of mouse hils1 gene expression during spermatogenesis: identification of regulatory element by transgenic mouse.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	ISO Inferred from Sequence Orthology more info
enables nucleosomal DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome condensation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromosome condensation	TAS Traceable Author Statement more info	PubMed
involved_in germ cell development	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone H1.9

Names: histone H1-like protein in spermatids 1; spermatid-specific linker histone H1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018792.2 → NP_061262.1 histone H1.9

See identical proteins and their annotated locations for NP_061262.1

Status: REVIEWED

Source sequence(s)

AL606480

Consensus CDS

CCDS25267.1

UniProtKB/Swiss-Prot

Q9QYL0

UniProtKB/TrEMBL

I6TGM1, I6UL39, Q5SWB1

Related

ENSMUSP00000039866.6, ENSMUST00000038928.7

Conserved Domains (1) summary

cl00073
Location:35 → 103

H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...