Plscr2 phospholipid scramblase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plscr2provided by MGI
Official Full Name: phospholipid scramblase 2provided by MGI
Primary source: MGI:MGI:1270860
See related: Ensembl:ENSMUSG00000032372 AllianceGenome:MGI:1270860
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding activity; and signaling receptor binding activity. Involved in cellular response to lipopolysaccharide. Located in cytoplasm and nucleus. Is expressed in foregut; inner ear; mesothelium; and urogenital mesentery. Orthologous to several human genes including PLSCR1 (phospholipid scramblase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 51.4), lung adult (RPKM 5.4) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 48.35 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (92157655..92179805)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (92275602..92297752)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLSCR2 is expressed predominantly in the cell nucleus
Title: Stimulation of phosphatidylserine biosynthesis and facilitation of UV-induced apoptosis in Chinese hamster ovary cells overexpressing phospholipid scramblase 1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CD4 receptor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables lead ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables mercury ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	ISO Inferred from Sequence Orthology more info
enables phospholipid scramblase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid scramblase activity	IEA Inferred from Electronic Annotation more info
enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine exposure on apoptotic cell surface	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane phospholipid scrambling	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane phospholipid scrambling	ISO Inferred from Sequence Orthology more info
involved_in regulation of Fc receptor mediated stimulatory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of mast cell activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phospholipid scramblase 2

Names: PL scramblase 2; ca(2+)-dependent phospholipid scramblase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195084.1 → NP_001182013.1 phospholipid scramblase 2

See identical proteins and their annotated locations for NP_001182013.1

Status: VALIDATED

Description

Transcript Variant: This variant (A) represents the longer transcript. Both variants A and B encode the same protein.

Source sequence(s)

AC111125

Consensus CDS

CCDS23405.1

UniProtKB/Swiss-Prot

O70233, Q921P6, Q9DCW2

Conserved Domains (2) summary

pfam03803
Location:84 → 304

Scramblase; Scramblase

cl23807
Location:10 → 61

WWbp; WW-domain ligand protein
NM_008880.3 → NP_032906.2 phospholipid scramblase 2

See identical proteins and their annotated locations for NP_032906.2

Status: VALIDATED

Description

Transcript Variant: This variant (B) differs in the 5' UTR compared to variant A. Both variants A and B encode the same protein.

Source sequence(s)

AC111125, AK002410, AW261539

Consensus CDS

CCDS23405.1

UniProtKB/Swiss-Prot

O70233, Q921P6, Q9DCW2

Related

ENSMUSP00000034932.8, ENSMUST00000034932.14

Conserved Domains (2) summary

pfam03803
Location:84 → 304

Scramblase; Scramblase

cl23807
Location:10 → 61

WWbp; WW-domain ligand protein