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    HERPUD2 HERPUD family member 2 [ Homo sapiens (human) ]

    Gene ID: 64224, updated on 4-Jan-2025

    Summary

    Official Symbol
    HERPUD2provided by HGNC
    Official Full Name
    HERPUD family member 2provided by HGNC
    Primary source
    HGNC:HGNC:21915
    See related
    Ensembl:ENSG00000122557 MIM:620829; AllianceGenome:HGNC:21915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis (RPKM 12.4), ovary (RPKM 12.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See HERPUD2 in Genome Data Viewer
    Location:
    7p14.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (35632659..35695135, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (35773637..35840411, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (35672269..35734745, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901614 Neighboring gene uncharacterized LOC101928421 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:35641191-35641691 Neighboring gene MPRA-validated peak6479 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:35733884-35734771 Neighboring gene HERPUD2 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 3013

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (22 hits/1259 screens)

    EBI GWAS Catalog

    Description
    Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • FLJ22313, FLJ31032

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response  
    involved_in spermatogenesis  
    Component Evidence Code Pubs
    located_in membrane  

    General protein information

    Preferred Names
    homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
    Names
    homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022373.5 → NP_071768.3  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

      See identical proteins and their annotated locations for NP_071768.3

      Status: VALIDATED

      Source sequence(s)
      AK315685, BC020264, DA282706, DA778088
      Consensus CDS
      CCDS5446.1
      UniProtKB/Swiss-Prot
      A4D1Y8, Q9BSE4, Q9H6F9
      Related
      ENSP00000310729.3, ENST00000311350.8
      Conserved Domains (2) summary
      cd01790
      Location:9 → 87
      Herp_N; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein
      smart00213
      Location:10 → 87
      UBQ; Ubiquitin homologues

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      35632659..35695135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006715765.3 → XP_006715828.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein isoform X2

      See identical proteins and their annotated locations for XP_006715828.1

      Conserved Domains (1) summary
      cl28922
      Location:9 → 51
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    2. XM_047420698.1 → XP_047276654.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein isoform X2

    3. XM_017012506.3 → XP_016867995.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein isoform X1

      UniProtKB/Swiss-Prot
      A4D1Y8, Q9BSE4, Q9H6F9
      Related
      ENSP00000379390.1, ENST00000396081.5
      Conserved Domains (2) summary
      cd01790
      Location:9 → 87
      Herp_N; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein
      smart00213
      Location:10 → 87
      UBQ; Ubiquitin homologues
    4. XM_047420699.1 → XP_047276655.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein isoform X3

      UniProtKB/TrEMBL
      C9J4Q7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      35773637..35840411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358786.1 → XP_054214761.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein isoform X2

    2. XM_054358785.1 → XP_054214760.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein isoform X1

      UniProtKB/Swiss-Prot
      A4D1Y8, Q9BSE4, Q9H6F9
    3. XM_054358787.1 → XP_054214762.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein isoform X2

    4. XM_054358788.1 → XP_054214763.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein isoform X3

      UniProtKB/TrEMBL
      C9J4Q7
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