Pard3 par-3 family cell polarity regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pard3provided by RGD
Official Full Name: par-3 family cell polarity regulatorprovided by RGD
Primary source: RGD:620374
See related: EnsemblRapid:ENSRNOG00000032437 AllianceGenome:RGD:620374
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Par3
Summary: Enables identical protein binding activity; phosphatidylinositol phosphate binding activity; and protein phosphatase binding activity. Involved in several processes, including bicellular tight junction assembly; establishment of epithelial cell polarity; and protein targeting to membrane. Located in axonal growth cone; cell-cell junction; and neuronal cell body. Part of protein-containing complex. Orthologous to human PARD3 (par-3 family cell polarity regulator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 82.9), Kidney (RPKM 67.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (71977420..72527273)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (55080282..55630111)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (60017746..60580628)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effect of Par3 on the cellular junctions and biological functions of odontoblast-lineage cells.
Title: The effect of Par3 on the cellular junctions and biological functions of odontoblast-lineage cells.
Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells.
Title: Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells.
Phosphorylation of Dab2 is involved in inhibited VEGF-VEGFR-2 signaling induced by downregulation of syndecan-1 in glomerular endothelial cell.
Title: Phosphorylation of Dab2 is involved in inhibited VEGF-VEGFR-2 signaling induced by downregulation of syndecan-1 in glomerular endothelial cell.
identify ASPP2 as a regulator of Par-3, which plays a key role in controlling cell proliferation, polarity, and tissue organization during CNS development
Title: ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development.
results identify a dual function of Par3 in skin cancer, with both pro-oncogenic and tumor-suppressive activity depending on the tumor type
Title: Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis.
Par3 emerges as a key molecule in the coupling of the early and late events needed for efficient extraction and processing of immobilized antigen by B-cells.
Title: Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse.
transcriptional upregulation of Girdin expression and Girdin-Galphai3 signaling play crucial roles in regulating epithelial apicobasal polarity through the PAR complex.
Title: Regulation of epithelial cell polarity by PAR-3 depends on Girdin transcription and Girdin-Gαi3 signaling.
PAR3 interacts with PAR6 and NGL-2, acting together to regulate axon differentiation.
Title: NGL-2 Is a New Partner of PAR Complex in Axon Differentiation.
Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
Title: Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
Report a willin(FRMD6)/Par3-aPKC-ROCK pathway that controls epithelial apical morphology.
Title: Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d19rat57 (e-PCR)
- UniSTS:121403

RH128030 (e-PCR)
- UniSTS:211339

D19Rat100 (e-PCR)
- UniSTS:239310

D19Rat99 (e-PCR)
- UniSTS:239832

RH143682 (e-PCR)
- UniSTS:232928

BE121212 (e-PCR)
- UniSTS:248035

RH133010 (e-PCR)
- UniSTS:216293

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apical constriction	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within centrosome localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of centrosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of epithelial cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	NAS Non-traceable Author Statement more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in myelination in peripheral nervous system	ISO Inferred from Sequence Orthology more info
involved_in myelination in peripheral nervous system	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of actin filament-based process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within wound healing, spreading of cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of PAR polarity complex	ISO Inferred from Sequence Orthology more info
located_in Schmidt-Lanterman incisure	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
is_active_in apical junction complex	IBA Inferred from Biological aspect of Ancestor more info
located_in apical junction complex	ISO Inferred from Sequence Orthology more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in internode region of axon	ISO Inferred from Sequence Orthology more info
located_in internode region of axon	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral loop	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: partitioning defective 3 homolog

Names: ASBP; ASIP; PARD-3; atypical PKC isotype-specific-interacting protein; atypical PKC-specific binding protein; par-3 (partitioning defective 3) homolog; three-PDZ containing protein similar to C. elegans PAR3 (partitioning defect)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431379.1 → NP_001418308.1 partitioning defective 3 homolog isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I6AK77
NM_001431380.1 → NP_001418309.1 partitioning defective 3 homolog isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I6AK77
NM_001431381.1 → NP_001418310.1 partitioning defective 3 homolog isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I5ZNZ7
NM_001431382.1 → NP_001418311.1 partitioning defective 3 homolog isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I6A9A7, A0A8I6AK77
NM_001431383.1 → NP_001418312.1 partitioning defective 3 homolog isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I5ZNZ7
NM_001431384.1 → NP_001418313.1 partitioning defective 3 homolog isoform 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I5ZN95
NM_001431385.1 → NP_001418314.1 partitioning defective 3 homolog isoform 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I5ZN95
NM_001431387.1 → NP_001418316.1 partitioning defective 3 homolog isoform 9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019
NM_001431389.1 → NP_001418318.1 partitioning defective 3 homolog isoform 10

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I6GMQ2
NM_031235.3 → NP_112514.1 partitioning defective 3 homolog isoform 1

See identical proteins and their annotated locations for NP_112514.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q9Z340

UniProtKB/TrEMBL

A0A8I6AK77, A6KJ58

Related

ENSRNOP00000075058.1, ENSRNOT00000078559.3

Conserved Domains (2) summary

cd00992
Location:465 → 544

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:1 → 146

DUF3534; Domain of unknown function (DUF3534)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

71977420..72527273

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017601371.3 → XP_017456860.2 partitioning defective 3 homolog isoform X19

Related

ENSRNOP00000097873.1, ENSRNOT00000105322.2

Conserved Domains (2) summary

cd00992
Location:465 → 544

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:2 → 83

DUF3534; N-terminal of Par3 and HAL proteins
XM_006255836.2 → XP_006255898.1 partitioning defective 3 homolog isoform X15

Related

ENSRNOP00000079670.2, ENSRNOT00000109223.2

Conserved Domains (2) summary

cd00992
Location:465 → 544

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:1 → 146

DUF3534; Domain of unknown function (DUF3534)
XM_017601370.3 → XP_017456859.2 partitioning defective 3 homolog isoform X18

Conserved Domains (2) summary

cd00992
Location:465 → 544

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:2 → 83

DUF3534; N-terminal of Par3 and HAL proteins
XM_006255828.2 → XP_006255890.1 partitioning defective 3 homolog isoform X2

Conserved Domains (2) summary

cd00992
Location:465 → 544

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:1 → 146

DUF3534; Domain of unknown function (DUF3534)
XM_039098024.2 → XP_038953952.1 partitioning defective 3 homolog isoform X4

Related

ENSRNOP00000092087.2, ENSRNOT00000111522.2

Conserved Domains (2) summary

cd00992
Location:465 → 544

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:2 → 83

DUF3534; N-terminal of Par3 and HAL proteins
XM_017601367.3 → XP_017456856.2 partitioning defective 3 homolog isoform X8

Conserved Domains (2) summary

cd00992
Location:465 → 544

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:2 → 83

DUF3534; N-terminal of Par3 and HAL proteins
XM_006255833.2 → XP_006255895.1 partitioning defective 3 homolog isoform X10

Related

ENSRNOP00000079662.1, ENSRNOT00000095548.2

Conserved Domains (2) summary

cd00992
Location:465 → 544

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:1 → 146

DUF3534; Domain of unknown function (DUF3534)
XM_006255837.2 → XP_006255899.1 partitioning defective 3 homolog isoform X17

Conserved Domains (2) summary

cd00992
Location:465 → 544

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:1 → 146

DUF3534; Domain of unknown function (DUF3534)
XM_039098022.2 → XP_038953950.1 partitioning defective 3 homolog isoform X1

UniProtKB/TrEMBL

A0A8I6AK77

Conserved Domains (2) summary

cd00992
Location:465 → 544

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:2 → 83

DUF3534; N-terminal of Par3 and HAL proteins
XM_063278311.1 → XP_063134381.1 partitioning defective 3 homolog isoform X5

UniProtKB/TrEMBL

A0A8I6AK77
XM_039098026.2 → XP_038953954.1 partitioning defective 3 homolog isoform X11

UniProtKB/TrEMBL

A0A8I5ZNZ7

Conserved Domains (2) summary

cd00992
Location:465 → 544

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:2 → 83

DUF3534; N-terminal of Par3 and HAL proteins
XM_006255830.2 → XP_006255892.1 partitioning defective 3 homolog isoform X6

UniProtKB/TrEMBL

A0A8I6AGY4, A0A8I6AK77

Conserved Domains (2) summary

cd00992
Location:465 → 544

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:1 → 146

DUF3534; Domain of unknown function (DUF3534)
XM_039098023.2 → XP_038953951.1 partitioning defective 3 homolog isoform X3

UniProtKB/TrEMBL

A0A8I6AK77

Related

ENSRNOP00000048964.5, ENSRNOT00000042623.6

Conserved Domains (2) summary

cd00992
Location:465 → 544

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:2 → 83

DUF3534; N-terminal of Par3 and HAL proteins
XM_039098025.2 → XP_038953953.1 partitioning defective 3 homolog isoform X7

UniProtKB/TrEMBL

A0A8I6AK77

Conserved Domains (2) summary

cd00992
Location:437 → 516

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:2 → 83

DUF3534; N-terminal of Par3 and HAL proteins
XM_063278312.1 → XP_063134382.1 partitioning defective 3 homolog isoform X9

Related

ENSRNOP00000089028.2, ENSRNOT00000104177.2
XM_017601369.2 → XP_017456858.2 partitioning defective 3 homolog isoform X14

UniProtKB/TrEMBL

A0A8I5ZN95

Conserved Domains (2) summary

cd00992
Location:465 → 544

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:2 → 83

DUF3534; N-terminal of Par3 and HAL proteins
XM_063278313.1 → XP_063134383.1 partitioning defective 3 homolog isoform X16

UniProtKB/TrEMBL

A0A8I5ZN95
XM_039098027.2 → XP_038953955.1 partitioning defective 3 homolog isoform X13

UniProtKB/TrEMBL

A0A8I6AK77

Conserved Domains (1) summary

cd00992
Location:175 → 254

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_017601368.3 → XP_017456857.1 partitioning defective 3 homolog isoform X12

UniProtKB/TrEMBL

A0A8I6AK77