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    Rims1 regulating synaptic membrane exocytosis 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84556, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rims1provided by RGD
    Official Full Name
    regulating synaptic membrane exocytosis 1provided by RGD
    Primary source
    RGD:620000
    See related
    EnsemblRapid:ENSRNOG00000011000 AllianceGenome:RGD:620000
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rim1; RIM1a
    Summary
    Enables SH3 domain binding activity; protein kinase binding activity; and small GTPase binding activity. Involved in long-term synaptic potentiation; positive regulation of inhibitory postsynaptic potential; and positive regulation of synaptic vesicle priming. Located in presynaptic membrane. Is active in glutamatergic synapse and presynaptic active zone cytoplasmic component. Orthologous to human RIMS1 (regulating synaptic membrane exocytosis 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 145.5), Uterus (RPKM 16.1) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rims1 in Genome Data Viewer
    Location:
    9q13
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (32193352..32692998, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (24696959..25196404, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (28440408..28973246, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480561 Neighboring gene ferritin light chain 1-like Neighboring gene KH domain containing 1B Neighboring gene potassium voltage-gated channel subfamily Q member 5 Neighboring gene uncharacterized LOC134480352 Neighboring gene heterogeneous nuclear ribonucleoprotein C, pseudogene 2 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 14B like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A trans-synaptic nanocolumn aligns neurotransmitter release to receptors. Tang AH, et al. Nature, 2016 Aug 11. PMID 27462810, Free PMC Article
    2. Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution. Guan R, et al. Biochemistry, 2007 Aug 7. PMID 17630786, Free PMC Article
    3. RIM1α SUMOylation is required for fast synaptic vesicle exocytosis. Girach F, et al. Cell Rep, 2013 Dec 12. PMID 24290762, Free PMC Article
    4. RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation. Wu X, et al. Mol Cell, 2019 Mar 7. PMID 30661983
    5. Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide. Lu J, et al. J Mol Biol, 2005 Sep 16. PMID 16095618

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RIM1a and RIM-BP2 are plausible organizers of active zones, and the formation of RIM and RIM-BP condensates may cluster voltage gated calcium channels into nano- or microdomains and position the clustered Ca(2+) channels with Ca(2+) sensors on docked vesicles for efficient and precise synaptic transmissions.
      Title: RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation.
    2. RIM1alpha SUMOylation at K502 is required for its binding to Cav2.1 and for fast synaptic vesicle exocytosis.
      Title: RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.
    3. Depletion of liprin-alpha2 resulted in reduced turnover of RIM1 and CASK at presynaptic terminals, suggesting that liprin-alpha2 promotes dynamic scaffolding for molecular complexes that facilitate synaptic vesicle release.
      Title: Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.
    4. Data show that Bassoon colocalizes with Aczonin at conventional synapses, but in ribbon synapses, CAST, Munc13, and RIM are segregated from Aczonin, and Aczonin is positioned and may control the access of neurotransmitter vesicles to the fusion site.
      Title: Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site.
    5. Presynaptic silencing was accompanied by decreases in levels of the priming proteins Munc13-1 and Rim1.
      Title: A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing.
    6. The crystal structure of the RIM1alpha C2B domain dimer reveals that it forms a beta-sandwich and that the unique N- and C-terminal extensions form a small subdomain that packs against the beta-sandwich and mediates dimerization.
      Title: Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution.
    7. These data demonstrate that alpha-RIMs are not essential for synapse formation or synaptic exocytosis, but are required for normal Ca(2+)-triggering of exocytosis.
      Title: Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.
    8. RIM1- or Bassoon-binding region of CAST impairs synaptic transmission in cultured superior cervical ganglion neurons.
      Title: Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release.
    9. Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2
      Title: Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosomal vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within calcium ion-regulated exocytosis of neurotransmitter ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of presynaptic active zone structure IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of inhibitory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of inhibitory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of inhibitory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of synaptic vesicle fusion to presynaptic active zone membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of synaptic vesicle priming IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in presynaptic dense core vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium-dependent activation of synaptic vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spontaneous neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle docking ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in inhibitory synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone cytoplasmic component IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic active zone cytoplasmic component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic active zone cytoplasmic component ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    regulating synaptic membrane exocytosis protein 1
    Names
    RIM 1
    Rab3 effector
    Rim1b protein
    rab-3-interacting molecule 1
    rab3-interacting molecule 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398595.2 → NP_001385524.1  regulating synaptic membrane exocytosis protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      UniProtKB/TrEMBL
      A0A0G2JT77
      Related
      ENSRNOP00000085276.2, ENSRNOT00000109109.2
      Conserved Domains (7) summary
      cd04028
      Location:1445 → 1590
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:887 → 1207
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    2. NM_052829.4 → NP_439894.2  regulating synaptic membrane exocytosis protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Related
      ENSRNOP00000015454.8, ENSRNOT00000015453.8
      Conserved Domains (6) summary
      cd04028
      Location:1384 → 1529
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      32193352..32692998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267779.1 → XP_063123849.1  regulating synaptic membrane exocytosis protein 1 isoform X9

      UniProtKB/TrEMBL
      F1LYS1

    2. XM_017596679.3 → XP_017452168.2  regulating synaptic membrane exocytosis protein 1 isoform X42

      UniProtKB/TrEMBL
      F1LYS1
      Conserved Domains (8) summary
      cd04028
      Location:1247 → 1392
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:702 → 828
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:379 → 496
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:877 → 1176
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:564 → 649
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:160 → 262
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:104 → 155
      FYVE_like_SF; FYVE domain like superfamily
      cl22851
      Location:26 → 149
      PHD_SF; PHD finger superfamily

    3. XM_039084268.2 → XP_038940196.1  regulating synaptic membrane exocytosis protein 1 isoform X10

      UniProtKB/TrEMBL
      F1LYS1
      Conserved Domains (8) summary
      cd04028
      Location:1419 → 1564
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:702 → 828
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:379 → 496
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:833 → 1187
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:564 → 649
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:160 → 262
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:104 → 155
      FYVE_like_SF; FYVE domain like superfamily
      cl22851
      Location:26 → 149
      PHD_SF; PHD finger superfamily

    4. XM_039084294.2 → XP_038940222.1  regulating synaptic membrane exocytosis protein 1 isoform X41

      UniProtKB/TrEMBL
      F1LYS1
      Conserved Domains (8) summary
      cd04028
      Location:1251 → 1396
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:706 → 832
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:383 → 500
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:881 → 1180
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:568 → 653
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:164 → 266
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:104 → 159
      FYVE_like_SF; FYVE domain like superfamily
      cl22851
      Location:26 → 153
      PHD_SF; PHD finger superfamily

    5. XM_017596678.3 → XP_017452167.2  regulating synaptic membrane exocytosis protein 1 isoform X8

      UniProtKB/TrEMBL
      F1LYS1
      Conserved Domains (8) summary
      cd04028
      Location:1423 → 1568
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:706 → 832
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:383 → 500
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:837 → 1191
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:568 → 653
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:164 → 266
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:104 → 159
      FYVE_like_SF; FYVE domain like superfamily
      cl22851
      Location:26 → 153
      PHD_SF; PHD finger superfamily

    6. XM_039084265.2 → XP_038940193.1  regulating synaptic membrane exocytosis protein 1 isoform X7

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Conserved Domains (7) summary
      cd04028
      Location:1446 → 1591
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:729 → 855
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:406 → 523
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:860 → 1214
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:591 → 676
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:187 → 289
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:127 → 182
      FYVE_like_SF; FYVE domain like superfamily

    7. XM_039084263.2 → XP_038940191.1  regulating synaptic membrane exocytosis protein 1 isoform X5

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Conserved Domains (7) summary
      cd04028
      Location:1449 → 1594
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:732 → 858
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:409 → 526
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:863 → 1217
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:594 → 679
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:190 → 292
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:130 → 185
      FYVE_like_SF; FYVE domain like superfamily

    8. XM_063267781.1 → XP_063123851.1  regulating synaptic membrane exocytosis protein 1 isoform X19

      UniProtKB/TrEMBL
      F1LYS1

    9. XM_039084261.2 → XP_038940189.1  regulating synaptic membrane exocytosis protein 1 isoform X4

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Conserved Domains (7) summary
      cd04028
      Location:1450 → 1595
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:733 → 859
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:410 → 527
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:864 → 1218
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:595 → 680
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:191 → 293
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:131 → 186
      FYVE_like_SF; FYVE domain like superfamily

    10. XM_039084259.2 → XP_038940187.1  regulating synaptic membrane exocytosis protein 1 isoform X2

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Conserved Domains (7) summary
      cd04028
      Location:1469 → 1614
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:752 → 878
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:429 → 546
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:883 → 1237
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:614 → 699
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:210 → 312
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 205
      FYVE_like_SF; FYVE domain like superfamily

    11. XM_039084264.2 → XP_038940192.1  regulating synaptic membrane exocytosis protein 1 isoform X6

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Conserved Domains (7) summary
      cd04028
      Location:1449 → 1594
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:955 → 1217
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    12. XM_039084287.2 → XP_038940215.1  regulating synaptic membrane exocytosis protein 1 isoform X34

      UniProtKB/TrEMBL
      A0A8I6GLS3
      Conserved Domains (6) summary
      cd04028
      Location:1137 → 1282
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    13. XM_039084279.2 → XP_038940207.1  regulating synaptic membrane exocytosis protein 1 isoform X25

      UniProtKB/TrEMBL
      A0A8I6GLS3
      Conserved Domains (6) summary
      cd04028
      Location:1300 → 1445
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    14. XM_017596670.3 → XP_017452159.2  regulating synaptic membrane exocytosis protein 1 isoform X23

      UniProtKB/TrEMBL
      A0A8I6GLS3
      Related
      ENSRNOP00000095741.2, ENSRNOT00000110625.2
      Conserved Domains (6) summary
      cd04028
      Location:1309 → 1454
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    15. XM_039084275.2 → XP_038940203.1  regulating synaptic membrane exocytosis protein 1 isoform X16

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Conserved Domains (6) summary
      cd04028
      Location:1370 → 1515
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    16. XM_039084285.2 → XP_038940213.1  regulating synaptic membrane exocytosis protein 1 isoform X32

      UniProtKB/TrEMBL
      A0A8I6GLS3
      Conserved Domains (6) summary
      cd04028
      Location:1161 → 1306
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    17. XM_039084277.2 → XP_038940205.1  regulating synaptic membrane exocytosis protein 1 isoform X20

      UniProtKB/TrEMBL
      A0A8I6GLS3
      Conserved Domains (6) summary
      cd04028
      Location:1333 → 1478
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    18. XM_039084271.2 → XP_038940199.1  regulating synaptic membrane exocytosis protein 1 isoform X13

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Conserved Domains (7) summary
      cd04028
      Location:1394 → 1539
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03381
      Location:999 → 1130
      PHA03381; tegument protein VP22; Provisional
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    19. XM_039084286.2 → XP_038940214.1  regulating synaptic membrane exocytosis protein 1 isoform X33

      UniProtKB/TrEMBL
      A0A8I6GLS3
      Conserved Domains (6) summary
      cd04028
      Location:1158 → 1303
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    20. XM_063267782.1 → XP_063123852.1  regulating synaptic membrane exocytosis protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A8I6GLS3

    21. XM_039084278.2 → XP_038940206.1  regulating synaptic membrane exocytosis protein 1 isoform X21

      UniProtKB/TrEMBL
      A0A8I6GLS3
      Conserved Domains (6) summary
      cd04028
      Location:1330 → 1475
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    22. XM_017596673.3 → XP_017452162.2  regulating synaptic membrane exocytosis protein 1 isoform X31

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Conserved Domains (6) summary
      cd04028
      Location:1188 → 1333
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    23. XM_039084276.2 → XP_038940204.1  regulating synaptic membrane exocytosis protein 1 isoform X18

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Conserved Domains (6) summary
      cd04028
      Location:1351 → 1496
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    24. XM_017596667.3 → XP_017452156.2  regulating synaptic membrane exocytosis protein 1 isoform X17

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Related
      ENSRNOP00000074013.3, ENSRNOT00000086967.3
      Conserved Domains (6) summary
      cd04028
      Location:1360 → 1505
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    25. XM_017596672.3 → XP_017452161.2  regulating synaptic membrane exocytosis protein 1 isoform X30

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Conserved Domains (6) summary
      cd04028
      Location:1212 → 1357
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    26. XM_039084274.2 → XP_038940202.1  regulating synaptic membrane exocytosis protein 1 isoform X15

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Conserved Domains (6) summary
      cd04028
      Location:1375 → 1520
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    27. XM_039084282.2 → XP_038940210.1  regulating synaptic membrane exocytosis protein 1 isoform X27

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Conserved Domains (7) summary
      cd04028
      Location:1273 → 1418
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:887 → 1202
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    28. XM_063267785.1 → XP_063123855.1  regulating synaptic membrane exocytosis protein 1 isoform X29

      UniProtKB/TrEMBL
      F1LYS1

    29. XM_039084273.2 → XP_038940201.1  regulating synaptic membrane exocytosis protein 1 isoform X14

      UniProtKB/TrEMBL
      F1LYS1
      Conserved Domains (7) summary
      cd04028
      Location:1388 → 1533
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      PHA02666
      Location:940 → 1129
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    30. XM_039084283.2 → XP_038940211.1  regulating synaptic membrane exocytosis protein 1 isoform X28

      UniProtKB/TrEMBL
      F1LYS1
      Conserved Domains (7) summary
      cd04028
      Location:1240 → 1385
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:885 → 1154
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    31. XM_039084270.2 → XP_038940198.1  regulating synaptic membrane exocytosis protein 1 isoform X12

      UniProtKB/TrEMBL
      F1LYS1
      Conserved Domains (7) summary
      cd04028
      Location:1403 → 1548
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:885 → 1154
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    32. XM_039084269.2 → XP_038940197.1  regulating synaptic membrane exocytosis protein 1 isoform X11

      UniProtKB/TrEMBL
      F1LYS1
      Conserved Domains (7) summary
      cd04028
      Location:1412 → 1557
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:885 → 1154
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    33. XM_017596671.3 → XP_017452160.2  regulating synaptic membrane exocytosis protein 1 isoform X24

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Conserved Domains (7) summary
      cd04028
      Location:1301 → 1446
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:931 → 1230
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    34. XM_039084260.2 → XP_038940188.1  regulating synaptic membrane exocytosis protein 1 isoform X3

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Conserved Domains (7) summary
      cd04028
      Location:1464 → 1609
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:887 → 1241
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    35. XM_017596657.3 → XP_017452146.2  regulating synaptic membrane exocytosis protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O35168, Q9JIR4
      Related
      ENSRNOP00000086155.2, ENSRNOT00000099201.2
      Conserved Domains (7) summary
      cd04028
      Location:1473 → 1618
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:887 → 1241
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    36. XM_063267783.1 → XP_063123853.1  regulating synaptic membrane exocytosis protein 1 isoform X26

      UniProtKB/TrEMBL
      F1LYS1

    37. XM_039084290.2 → XP_038940218.1  regulating synaptic membrane exocytosis protein 1 isoform X36

      UniProtKB/TrEMBL
      A6JJA0
      Conserved Domains (4) summary
      cd04028
      Location:938 → 1083
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:221 → 347
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:352 → 706
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:83 → 168
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    38. XM_039084292.2 → XP_038940220.1  regulating synaptic membrane exocytosis protein 1 isoform X38

      UniProtKB/TrEMBL
      A6JJA0
      Conserved Domains (4) summary
      cd04028
      Location:852 → 997
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:135 → 261
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:266 → 620
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:1 → 82
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    39. XM_039084291.2 → XP_038940219.1  regulating synaptic membrane exocytosis protein 1 isoform X37

      UniProtKB/TrEMBL
      A6JJA0
      Conserved Domains (4) summary
      cd04028
      Location:903 → 1048
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:186 → 312
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:317 → 671
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:48 → 133
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    40. XM_039084293.2 → XP_038940221.1  regulating synaptic membrane exocytosis protein 1 isoform X39

      Conserved Domains (1) summary
      cd04028
      Location:229 → 374
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

    41. XM_063267786.1 → XP_063123856.1  regulating synaptic membrane exocytosis protein 1 isoform X40

    42. XM_039084288.2 → XP_038940216.1  regulating synaptic membrane exocytosis protein 1 isoform X35

      Conserved Domains (6) summary
      cd04031
      Location:756 → 882
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:433 → 550
      PLN03237; DNA topoisomerase 2; Provisional
      PHA03307
      Location:887 → 1241
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:618 → 703
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    RNA

    1. XR_010054639.1 RNA Sequence

    2. XR_010054638.1 RNA Sequence

    3. XR_010054637.1 RNA Sequence

    4. XR_010054636.1 RNA Sequence

    5. XR_005488976.2 RNA Sequence

    6. XR_005488975.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIR4.1 GenPept UniProtKB/Swiss-Prot:Q9JIR4

    Gene LinkOut

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