Adgrl3 adhesion G protein-coupled receptor L3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adgrl3provided by RGD
Official Full Name: adhesion G protein-coupled receptor L3provided by RGD
Primary source: RGD:620836
See related: EnsemblRapid:ENSRNOG00000030149 AllianceGenome:RGD:620836
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lec3; Cirl3; Lphn3; CIRL-3
Summary: Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Predicted to be involved in several processes, including locomotion involved in locomotory behavior; response to cocaine; and synapse organization. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic membrane. Orthologous to human ADGRL3 (adhesion G protein-coupled receptor L3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 164.5), Lung (RPKM 131.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p21

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (26690891..27458132, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (26336320..27104060, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (28362176..29226085, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity.
Title: Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity.
A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats.
Title: A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats.
Enhanced Transient Striatal Dopamine Release and Reuptake in Lphn3 Knockout Rats.
Title: Enhanced Transient Striatal Dopamine Release and Reuptake in Lphn3 Knockout Rats.
new Lphn3 knockout-out rat data collectively show that its disruption is significantly correlated with hyperactivity and associated striatal changes in dopamine markers.
Title: Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE107836 (e-PCR)
- UniSTS:247087

D14Rat41 (e-PCR), detects polymorphism
- UniSTS:226648

RH144064 (e-PCR)
- UniSTS:233310

RH131601 (e-PCR)
- UniSTS:214884

BF397398 (e-PCR)
- UniSTS:246152

D1S3698 (e-PCR)
- UniSTS:474276

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in locomotion involved in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in maintenance of postsynaptic specialization structure	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor L3

Names: calcium-independent alpha-latrotoxin receptor 3; calcium-independent alpha-latrotoxin receptor homolog 3; latrophilin-3; lectomedin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130822.2 → NP_570835.2 adhesion G protein-coupled receptor L3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

O88924, O88925, O88926, O88927, O88928, O88929, Q4LDM4, Q4LDM5, Q4LDM6, Q4LDM7, Q4LDM8, Q9Z173

UniProtKB/TrEMBL

A0A8I6GLK1

Related

ENSRNOP00000099227.1, ENSRNOT00000131643.1

Conserved Domains (5) summary

smart00284
Location:205 → 461

OLF; Olfactomedin-like domains

PLN03059
Location:111 → 191

PLN03059; beta-galactosidase; Provisional

smart00303
Location:881 → 933

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:562 → 626

HormR; Domain present in hormone receptors

cd16005
Location:941 → 1207

7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

26690891..27458132 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272835.1 → XP_063128905.1 adhesion G protein-coupled receptor L3 isoform X20

UniProtKB/TrEMBL

A6JCU0
XM_063272833.1 → XP_063128903.1 adhesion G protein-coupled receptor L3 isoform X18

UniProtKB/TrEMBL

A6JCU0
XM_063272832.1 → XP_063128902.1 adhesion G protein-coupled receptor L3 isoform X17

UniProtKB/TrEMBL

A6JCU0
XM_063272834.1 → XP_063128904.1 adhesion G protein-coupled receptor L3 isoform X19

UniProtKB/TrEMBL

A6JCU0
XM_063272831.1 → XP_063128901.1 adhesion G protein-coupled receptor L3 isoform X13

UniProtKB/TrEMBL

A6JCT4
XM_063272830.1 → XP_063128900.1 adhesion G protein-coupled receptor L3 isoform X12

UniProtKB/TrEMBL

A6JCT4
XM_063272829.1 → XP_063128899.1 adhesion G protein-coupled receptor L3 isoform X11

UniProtKB/TrEMBL

A6JCT4
XM_063272828.1 → XP_063128898.1 adhesion G protein-coupled receptor L3 isoform X10

UniProtKB/TrEMBL

A6JCT4

Related

ENSRNOP00000083229.2, ENSRNOT00000112088.2
XM_063272823.1 → XP_063128893.1 adhesion G protein-coupled receptor L3 isoform X7

UniProtKB/TrEMBL

A6JCT4
XM_063272820.1 → XP_063128890.1 adhesion G protein-coupled receptor L3 isoform X3

UniProtKB/TrEMBL

A6JCT7
XM_039091582.2 → XP_038947510.1 adhesion G protein-coupled receptor L3 isoform X8

UniProtKB/TrEMBL

A0A8I5ZV15, A6JCT5

Conserved Domains (7) summary

smart00284
Location:200 → 456

OLF; Olfactomedin-like domains

smart00303
Location:863 → 915

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:557 → 621

HormR; Domain present in hormone receptors

cd16005
Location:923 → 1180

7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:111 → 191

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1180 → 1509

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:629 → 837

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_063272822.1 → XP_063128892.1 adhesion G protein-coupled receptor L3 isoform X5

UniProtKB/TrEMBL

A6JCT7
XM_039091579.2 → XP_038947507.1 adhesion G protein-coupled receptor L3 isoform X6

UniProtKB/TrEMBL

A6JCT5

Conserved Domains (7) summary

smart00284
Location:200 → 456

OLF; Olfactomedin-like domains

smart00303
Location:876 → 928

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:557 → 621

HormR; Domain present in hormone receptors

cd16005
Location:936 → 1193

7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:111 → 191

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1193 → 1522

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:629 → 850

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_039091587.2 → XP_038947515.1 adhesion G protein-coupled receptor L3 isoform X16

UniProtKB/TrEMBL

A0A8I5ZWD6, A6JCU0

Conserved Domains (7) summary

smart00284
Location:200 → 456

OLF; Olfactomedin-like domains

smart00303
Location:876 → 928

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:557 → 621

HormR; Domain present in hormone receptors

cd16005
Location:936 → 1193

7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:111 → 191

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1193 → 1256

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:629 → 850

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_063272821.1 → XP_063128891.1 adhesion G protein-coupled receptor L3 isoform X4

UniProtKB/TrEMBL

A6JCT7
XM_039091585.2 → XP_038947513.1 adhesion G protein-coupled receptor L3 isoform X15

UniProtKB/TrEMBL

A6JCU0

Conserved Domains (8) summary

smart00284
Location:200 → 456

OLF; Olfactomedin-like domains

smart00303
Location:876 → 928

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:557 → 621

HormR; Domain present in hormone receptors

pfam02140
Location:111 → 191

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1202 → 1265

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:629 → 850

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cd14964
Location:938 → 963

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:936 → 1202

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_017599059.3 → XP_017454548.1 adhesion G protein-coupled receptor L3 isoform X1

UniProtKB/TrEMBL

A6JCT7
XM_039091584.2 → XP_038947512.1 adhesion G protein-coupled receptor L3 isoform X14

UniProtKB/TrEMBL

F1LRG7

Related

ENSRNOP00000056687.5, ENSRNOT00000059942.7

Conserved Domains (8) summary

smart00284
Location:200 → 456

OLF; Olfactomedin-like domains

smart00303
Location:876 → 928

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:557 → 621

HormR; Domain present in hormone receptors

pfam02140
Location:111 → 191

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1202 → 1309

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:629 → 850

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cd14964
Location:938 → 963

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:936 → 1202

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_008769970.4 → XP_008768192.1 adhesion G protein-coupled receptor L3 isoform X2

UniProtKB/TrEMBL

A6JCT7, D4AAL4

Related

ENSRNOP00000045365.6, ENSRNOT00000044659.7

Conserved Domains (8) summary

smart00284
Location:205 → 461

OLF; Olfactomedin-like domains

smart00303
Location:881 → 933

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:562 → 626

HormR; Domain present in hormone receptors

COG0531
Location:951 → 1178

PotE; Amino acid transporter [Amino acid transport and metabolism]

pfam00002
Location:941 → 1186

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02140
Location:111 → 191

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1207 → 1579

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:635 → 853

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_063272826.1 → XP_063128896.1 adhesion G protein-coupled receptor L3 isoform X8

UniProtKB/TrEMBL

A0A8I5ZV15, A6JCT5
XM_063272818.1 → XP_063128888.1 adhesion G protein-coupled receptor L3 isoform X1

UniProtKB/TrEMBL

A6JCT7
XM_063272825.1 → XP_063128895.1 adhesion G protein-coupled receptor L3 isoform X7

UniProtKB/TrEMBL

A6JCT4

Related

ENSRNOP00000039467.7, ENSRNOT00000048175.8
XM_063272827.1 → XP_063128897.1 adhesion G protein-coupled receptor L3 isoform X9

UniProtKB/TrEMBL

A6JCT5

Related

ENSRNOP00000096360.2, ENSRNOT00000100277.2
XM_063272824.1 → XP_063128894.1 adhesion G protein-coupled receptor L3 isoform X7

UniProtKB/TrEMBL

A6JCT4
XM_063272819.1 → XP_063128889.1 adhesion G protein-coupled receptor L3 isoform X1

UniProtKB/TrEMBL

A6JCT7