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    Dll3 delta like canonical Notch ligand 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114125, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dll3provided by RGD
    Official Full Name
    delta like canonical Notch ligand 3provided by RGD
    Primary source
    RGD:70953
    See related
    EnsemblRapid:ENSRNOG00000019338 AllianceGenome:RGD:70953
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables Notch binding activity. Involved in negative regulation of Notch signaling pathway; negative regulation of astrocyte differentiation; and positive regulation of neurogenesis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis 1. Orthologous to human DLL3 (delta like canonical Notch ligand 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 16.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dll3 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (92689577..92698125, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (83562011..83570008, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (85485875..85493683)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene EP300 interacting inhibitor of differentiation 2B Neighboring gene selenoprotein V Neighboring gene translocase of inner mitochondrial membrane 50 Neighboring gene SPT5 homolog, DSIF elongation factor subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. Ladi E, et al. J Cell Biol, 2005 Sep 12. PMID 16144902, Free PMC Article
    2. Diverse requirements for Notch signalling in mammals. Sparrow DB, et al. Int J Dev Biol, 2002. PMID 12141422
    3. Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Bulman MP, et al. Nat Genet, 2000 Apr. PMID 10742114
    4. Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells. Irvin DK, et al. J Neurosci Res, 2004 Feb 1. PMID 14743446
    5. Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes. Kusumi K, et al. Genesis, 2004 Jun. PMID 15170697

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Notch binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables Notch binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate determination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in compartment pattern specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within compartment pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of astrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in paraxial mesoderm development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within paraxial mesoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neurogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within somitogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    delta-like protein 3
    Names
    delta3
    drosophila Delta homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053666.2 → NP_446118.2  delta-like protein 3 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O88671
      UniProtKB/TrEMBL
      F1M9P5
      Related
      ENSRNOP00000026182.3, ENSRNOT00000026182.6
      Conserved Domains (2) summary
      cd00054
      Location:281 → 312
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07657
      Location:25 → 82
      MNNL; N-terminus of Notch ligand

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      92689577..92698125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228611.5 → XP_006228673.1  delta-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006228673.1

      UniProtKB/Swiss-Prot
      O88671
      UniProtKB/TrEMBL
      A6J9H5
      Conserved Domains (3) summary
      cd00054
      Location:277 → 308
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07657
      Location:25 → 82
      MNNL; N terminus of Notch ligand
      cl19567
      Location:156 → 246
      DSL; Delta serrate ligand
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88671.1 GenPept UniProtKB/Swiss-Prot:O88671

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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