Mpdz multiple PDZ domain crumbs cell polarity complex component [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mpdzprovided by RGD
Official Full Name: multiple PDZ domain crumbs cell polarity complex componentprovided by RGD
Primary source: RGD:3105
See related: EnsemblRapid:ENSRNOG00000007894 AllianceGenome:RGD:3105
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in myelination. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human MPDZ (multiple PDZ domain crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 147.0), Heart (RPKM 118.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q31

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (100812121..100966566, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (95766112..95920531, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (99413184..99566356, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the dendrite and synapse, MUPP1 transports GPR37.
Title: CASPR2 forms a complex with GPR37 via MUPP1 but not with GPR37(R558Q), an autism spectrum disorder-related mutation.
CaMKIIalpha interacts with MUPP1 in spermatozoa to prevents spontaneous acrosomal exocytosis.
Title: CaMKIIalpha interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis.
MUPP1-SynGAPalpha complex dissociation triggers a mechanism for AMPAR enhancement that is distinct from activity-induced long term potentiation
Title: The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTP.
This evidence points to a role of MUPP1 as a membrane raft-associated molecular organizer, suggesting that mammalian spermatozoa may use a scaffolding protein and membrane subdomains to organize components involved in the process of acrosomal exocytosis.
Title: The Multi-PDZ domain protein MUPP1 as a lipid raft-associated scaffolding protein controlling the acrosome reaction in mammalian spermatozoa.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU027586 (e-PCR)
- UniSTS:113160

RH138353 (e-PCR)
- UniSTS:220440

Mpdz (e-PCR), detects polymorphism
- UniSTS:143902

AU028838 (e-PCR)
- UniSTS:111939

RH134440 (e-PCR)
- UniSTS:217720

AU046394 (e-PCR)
- UniSTS:111482

D5Rat98 (e-PCR)
- UniSTS:118941

RH47575 (e-PCR)
- UniSTS:38359

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in dendrite development	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in myelination	IPI Inferred from Physical Interaction more info	PubMed
involved_in tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Schmidt-Lanterman incisure	ISO Inferred from Sequence Orthology more info
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apicolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
part_of subapical complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: multiple PDZ domain protein

Names: multi-PDZ domain protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429635.1 → NP_001416564.1 multiple PDZ domain protein isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2K2Y8
NM_001429636.1 → NP_001416565.1 multiple PDZ domain protein isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8L2QPJ0
NM_019196.2 → NP_062069.1 multiple PDZ domain protein isoform 2

See identical proteins and their annotated locations for NP_062069.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O55164

UniProtKB/TrEMBL

A0A8I6AGX6, A6J832

Related

ENSRNOP00000107991.1, ENSRNOT00000154665.1

Conserved Domains (4) summary

pfam09045
Location:6 → 63

L27_2; L27_2

smart00228
Location:374 → 463

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1136 → 1227

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16667
Location:1549 → 1610

MPDZ_u10; Unstructured region 10 on multiple PDZ protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

100812121..100966566 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287256.1 → XP_063143326.1 multiple PDZ domain protein isoform X10
XM_063287255.1 → XP_063143325.1 multiple PDZ domain protein isoform X7

Related

ENSRNOP00000095980.2, ENSRNOT00000108047.2
XM_006238342.5 → XP_006238404.1 multiple PDZ domain protein isoform X5

UniProtKB/TrEMBL

A0A8I6GLE5

Conserved Domains (4) summary

pfam09045
Location:6 → 63

L27_2; L27_2

smart00228
Location:374 → 463

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1111 → 1202

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16667
Location:1524 → 1585

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_039109364.2 → XP_038965292.1 multiple PDZ domain protein isoform X3

UniProtKB/TrEMBL

A0A8I6AGX6

Conserved Domains (4) summary

smart00228
Location:374 → 463

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1132 → 1223

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1545 → 1606

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_039109365.2 → XP_038965293.1 multiple PDZ domain protein isoform X9

UniProtKB/TrEMBL

A0A8I6AAR0, A0A8I6GLE5

Conserved Domains (4) summary

smart00228
Location:374 → 463

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1900 → 1983

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1479 → 1540

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_006238343.5 → XP_006238405.1 multiple PDZ domain protein isoform X6

Conserved Domains (4) summary

pfam09045
Location:6 → 63

L27_2; L27_2

smart00228
Location:374 → 463

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1136 → 1227

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16667
Location:1516 → 1577

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_006238344.5 → XP_006238406.1 multiple PDZ domain protein isoform X8

UniProtKB/TrEMBL

A0A8I6GLE5

Related

ENSRNOP00000088952.2, ENSRNOT00000105796.2

Conserved Domains (4) summary

pfam09045
Location:6 → 63

L27_2; L27_2

smart00228
Location:374 → 463

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1914 → 1997

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16667
Location:1493 → 1554

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_006238341.5 → XP_006238403.1 multiple PDZ domain protein isoform X4

UniProtKB/TrEMBL

A0A8I6GLE5

Related

ENSRNOP00000051321.5, ENSRNOT00000051028.5

Conserved Domains (4) summary

pfam09045
Location:6 → 63

L27_2; L27_2

smart00228
Location:374 → 463

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1150 → 1241

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16667
Location:1530 → 1591

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_039109363.2 → XP_038965291.1 multiple PDZ domain protein isoform X2

UniProtKB/TrEMBL

A0A8I6AGX6

Conserved Domains (4) summary

smart00228
Location:374 → 463

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1150 → 1241

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1563 → 1624

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_006238340.5 → XP_006238402.1 multiple PDZ domain protein isoform X1

Related

ENSRNOP00000072433.1, ENSRNOT00000089235.3

Conserved Domains (4) summary

pfam09045
Location:6 → 63

L27_2; L27_2

smart00228
Location:374 → 463

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1150 → 1241

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16667
Location:1563 → 1624

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_039109366.2 → XP_038965294.1 multiple PDZ domain protein isoform X11

Conserved Domains (3) summary

smart00228
Location:763 → 847

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:288 → 379

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16667
Location:701 → 762

MPDZ_u10; Unstructured region 10 on multiple PDZ protein