Tshr thyroid stimulating hormone receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tshrprovided by RGD
Official Full Name: thyroid stimulating hormone receptorprovided by RGD
Primary source: RGD:3911
See related: EnsemblRapid:ENSRNOG00000003972 AllianceGenome:RGD:3911
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TSHRA
Summary: Enables thyroid-stimulating hormone receptor activity. Involved in positive regulation of cell population proliferation. Predicted to be located in basolateral plasma membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); cardiomyopathy; hyperthyroidism (multiple); and mitral valve prolapse. Orthologous to human TSHR (thyroid stimulating hormone receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 17.6), Lung (RPKM 14.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q31

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (116072321..116206009)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (110341585..110475297)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (115170290..115306871)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thyroid-stimulating hormone receptor signaling restores skeletal muscle stem cell regeneration in rats with muscular dystrophy.
Title: Thyroid-stimulating hormone receptor signaling restores skeletal muscle stem cell regeneration in rats with muscular dystrophy.
Expression and Role of Thyrotropin Receptors in Proopiomelanocortin-Producing Pituitary Cells.
Title: Expression and Role of Thyrotropin Receptors in Proopiomelanocortin-Producing Pituitary Cells.
Allylpyrocatechol, isolated from betel leaf ameliorates thyrotoxicosis in rats by altering thyroid peroxidase and thyrotropin receptors.
Title: Allylpyrocatechol, isolated from betel leaf ameliorates thyrotoxicosis in rats by altering thyroid peroxidase and thyrotropin receptors.
Data suggest that functional thyroid-stimulating hormone receptor is present in the caudal brainstem and hypothalamic nuclei of relevance for feeding control as a possibly uncleaved holoreceptor, and highlights a hindbrain component to central thyroid-stimulating hormone inhibition of food intake.
Title: Presence of TSH receptors in discrete areas of the hypothalamus and caudal brainstem with relevance for feeding controls-Support for functional significance.
TSH signal transduction in cultured tanycytes signals via G alphas to increase cAMP via an alternative G protein to increase phosphorylation of ERK1/2.
Title: Dual signal transduction pathways activated by TSH receptors in rat primary tanycyte cultures.
Results show that Tshr mRNA levels were up-regulated during differentiation of brown adipocytes. During the differentiation of brown adipocytes
Title: TSH effects on thermogenesis in rat brown adipocytes.
Higher TSH level in the BN strain appears to reflect an adjustment of the feedback loop to reduced thyrocyte sensitivity to TSH secondary to reduced TSHR expression.
Title: Pituitary-thyroid setpoint and thyrotropin receptor expression in consomic rats.
TSHR is present and functional in hepatocytes.
Title: Presence of thyrotropin receptor in hepatocytes: not a case of illegitimate transcription.
Data indicate that the presence of thyrostimulin in the ovary suggests that it may have a primitive function in reproduction when it activates ovarian TSHR.
Title: Thyrostimulin, but not thyroid-stimulating hormone (TSH), acts as a paracrine regulator to activate the TSH receptor in mammalian ovary.
Developmental profiles of TSH, sex steroids, and their receptors in the thyroid and their relevance to thyroid growth in immature rats
Title: Developmental profiles of TSH, sex steroids, and their receptors in the thyroid and their relevance to thyroid growth in immature rats.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

PMC102181P1 (e-PCR)
- UniSTS:270083

RH144511 (e-PCR)
- UniSTS:233756

Tshr (e-PCR), detects polymorphism
- UniSTS:516183

RH94520 (e-PCR)
- UniSTS:119768

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables thyroid-stimulating hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyroid-stimulating hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables thyroid-stimulating hormone receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables thyroid-stimulating hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables thyroid-stimulating hormone receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glycoprotein	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glycoprotein	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to thyrotropin-releasing hormone	ISO Inferred from Sequence Orthology more info
involved_in cellular response to thyrotropin-releasing hormone	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner ear receptor cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of locomotion	ISO Inferred from Sequence Orthology more info
involved_in thyroid-stimulating hormone signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in thyroid-stimulating hormone signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in thyroid-stimulating hormone signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thyrotropin receptor

Names: TSH-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012888.2 → NP_037020.2 thyrotropin receptor precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

P21463

UniProtKB/TrEMBL

A6JEC7, G3V6J1

Related

ENSRNOP00000005671.2, ENSRNOT00000005671.6

Conserved Domains (3) summary

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

cd15964
Location:415 → 689

7tmA_TSH-R; thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors

pfam13306
Location:65 → 221

LRR_5; Leucine rich repeats (6 copies)