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    Arsb arylsulfatase B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25227, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arsbprovided by RGD
    Official Full Name
    arylsulfatase Bprovided by RGD
    Primary source
    RGD:2158
    See related
    EnsemblRapid:ENSRNOG00000011150 AllianceGenome:RGD:2158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables sulfuric ester hydrolase activity. Involved in several processes, including positive regulation of neuron projection development; response to estrogen; and response to methylmercury. Located in cell surface. Used to study mucopolysaccharidosis VI. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to human ARSB (arylsulfatase B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 330.0), Adrenal (RPKM 238.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arsb in Genome Data Viewer
    Location:
    2q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (26736395..26895682)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (25002210..25162675)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (23385154..23543028)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene betaine-homocysteine S-methyltransferase 2 Neighboring gene dimethylglycine dehydrogenase Neighboring gene small nucleolar RNA SNORA48 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene uncharacterized LOC120100667 Neighboring gene LHFPL tetraspan subfamily member 2 Neighboring gene SNRPN upstream open reading frame, pseudogene 1 Neighboring gene small nuclear ribonucleoprotein polypeptide N, pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Arylsulfatase B modulates neurite outgrowth via astrocyte chondroitin-4-sulfate: dysregulation by ethanol. Zhang X, et al. Glia, 2014 Feb. PMID 24311516, Free PMC Article
    2. Localization of arylsulphatase A and B activities in rat kidney. Leźnicki AJ, et al. Acta Biochim Pol, 1991. PMID 1686699
    3. Characterization of liver lysosomal enzyme activity in hepatocytes, Kupffer and endothelial cells during aging: effect of dietary restriction. Ferland G, et al. Mech Ageing Dev, 1990 Nov. PMID 2290353
    4. Isolation and characterization of rat hepatic ascorbic acid-2-sulfatases. Thompson DB, et al. Enzyme, 1987. PMID 2884099
    5. Ultrastructural localization of arylsulfatase B in mitochondria of epithelial cells of the proximal convoluted tubules of the rat kidney. Makita T, et al. Experientia, 1971 Feb 15. PMID 5544743

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetylgalactosamine-4-sulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetylgalactosamine-4-sulfatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables N-acetylgalactosamine-6-sulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arylsulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arylsulfatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfuric ester hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior head development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in colon epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in colon epithelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dermatan sulfate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of epithelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to estrogen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to methylmercury IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to nutrient IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to pH IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    arylsulfatase B
    Names
    ASB
    Arylsulfatase B (MPS VI)
    G4S
    N-acetylgalactosamine-4-sulfatase
    NP_254278.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033443.1 → NP_254278.1  arylsulfatase B precursor

      See identical proteins and their annotated locations for NP_254278.1

      Status: VALIDATED

      Source sequence(s)
      AI071950, CF113828, CK482953, D49434
      UniProtKB/Swiss-Prot
      P50430, Q32KK1
      UniProtKB/TrEMBL
      A6I4W1, B4F7E2
      Related
      ENSRNOP00000014860.5, ENSRNOT00000014860.8
      Conserved Domains (2) summary
      COG3119
      Location:36 → 484
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16029
      Location:40 → 483
      4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      26736395..26895682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005500242.2 RNA Sequence

    2. XR_005500243.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50430.2 GenPept UniProtKB/Swiss-Prot:P50430

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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