Gip gastric inhibitory polypeptide [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gipprovided by RGD
Official Full Name: gastric inhibitory polypeptideprovided by RGD
Primary source: RGD:2709
See related: EnsemblRapid:ENSRNOG00000006306 AllianceGenome:RGD:2709
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gludins; RATGLUDINS
Summary: Enables signaling receptor binding activity. Involved in several processes, including positive regulation of D-glucose transmembrane transport; positive regulation of cell communication; and triglyceride homeostasis. Located in extracellular space and neuronal cell body. Used to study type 2 diabetes mellitus. Biomarker of hyperinsulinism; hypothyroidism; obesity; and pancreas disease. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human GIP (gastric inhibitory polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (81465070..81473216)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (80968360..80976506)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (83835080..83848399)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GK-rats respond to gastric bypass surgery with improved glycemia despite unaffected insulin secretion and beta cell mass.
Title: GK-rats respond to gastric bypass surgery with improved glycemia despite unaffected insulin secretion and beta cell mass.
GIP-GIPR promotes neurite outgrowth of cortical neurons in Akt dependent manner.
Title: GIP-GIPR promotes neurite outgrowth of cortical neurons in Akt dependent manner.
Sitagliptin attenuated resistin expression via the GIP-dependent pathway, which inhibited sympathetic innervation through a signalling pathway involving phosphatidylinositol 3-kinase (PI3K) and Akt protein.
Title: Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats.
provide evidence that gastric inhibitory polypeptide regulates skeletal muscle glucose transport; however, the exact signaling mechanism(s) remain unknown
Title: Glucose-dependent insulinotropic polypeptide directly induces glucose transport in rat skeletal muscle.
glucose-dependent insulinotropic polypeptide and Glucose-dependent insulinotropic polypeptide receptors expression in the rat major salivary glands, as well as its variation in the rat SMG during the growth period
Title: Expression of glucose-dependent insulinotropic polypeptide and its receptor in the rat major salivary glands.
The role of GIP as a critical link between catch-up growth and the development of metabolic disturbances.
Title: Predominant role of GIP in the development of a metabolic syndrome-like phenotype in female Wistar rats submitted to forced catch-up growth.
In a HFD model, DPP4-rats exhibited reduced adipose tissue inflammation and improved insulin resistance, which may be mediated in part by GIP induction of adiponectin.
Title: Role of glucose-dependent insulinotropic polypeptide in adipose tissue inflammation of dipeptidylpeptidase 4-deficient rats.
Changes in the secretion and action of GIP play an important role in metabolic adaptations during pregnancy and especially lactation.
Title: Alterations of glucose-dependent insulinotropic polypeptide and expression of genes involved in mammary gland and adipose tissue lipid metabolism during pregnancy and lactation.
Dietary fructose elicits GLP-1 secretion without simultaneous release of glucagonotropic GIP.
Title: Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans.
Data suggest that secretion of GIP and GLP1 (glucagon-like peptide-1) by enterocytes (in rats with diabetes type 2 and in normal rats) can be up-regulated by dietary factors, here, corn zein hydrolysate as a hypoglycemic dietary supplement.
Title: Oral administration of corn zein hydrolysate stimulates GLP-1 and GIP secretion and improves glucose tolerance in male normal rats and Goto-Kakizaki rats.

Submit: New GeneRIF Correction See all GeneRIFs (30)

General gene information

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Markers

PMC26408P2 (e-PCR)
- UniSTS:143208

Gip (e-PCR), detects polymorphism
- UniSTS:143208

D10Wox23 (e-PCR)
- UniSTS:517820

D10Got113 (e-PCR)
- UniSTS:115419

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables gastric inhibitory polypeptide receptor binding	ISO Inferred from Sequence Orthology more info
enables glucagon receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in digestive system development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within endocrine pancreas development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in gastric inhibitory peptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of D-glucose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cAMP/PKA signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of insulin secretion	TAS Traceable Author Statement more info	PubMed
involved_in response to acidic pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to carbohydrate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to selenium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gastric inhibitory polypeptide

Names: Glucose-dependent insulinotropic peptide; glucose-dependent insulinotropic polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019630.4 → NP_062604.1 gastric inhibitory polypeptide precursor

See identical proteins and their annotated locations for NP_062604.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q06145

UniProtKB/TrEMBL

A6HIC4

Related

ENSRNOP00000008481.5, ENSRNOT00000008481.8

Conserved Domains (1) summary

pfam00123
Location:44 → 71

Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

81465070..81473216

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247177.5 → XP_006247239.1 gastric inhibitory polypeptide isoform X2

Related

ENSRNOP00000103104.1, ENSRNOT00000132804.1

Conserved Domains (2) summary

smart00070
Location:91 → 117

GLUCA; Glucagon like hormones

cl21460
Location:110 → 182

HAD_like; Haloacid Dehalogenase-like Hydrolases
XM_039085248.1 → XP_038941176.1 gastric inhibitory polypeptide isoform X1

Conserved Domains (1) summary

pfam00123
Location:91 → 118

Hormone_2; Peptide hormone