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    Spr sepiapterin reductase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29270, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sprprovided by RGD
    Official Full Name
    sepiapterin reductaseprovided by RGD
    Primary source
    RGD:3753
    See related
    EnsemblRapid:ENSRNOG00000015455 AllianceGenome:RGD:3753
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables sepiapterin reductase (NADP+) activity. Involved in positive regulation of cell population proliferation and tetrahydrobiopterin biosynthetic process. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 299.0), Liver (RPKM 294.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spr in Genome Data Viewer
    Location:
    4q34
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (119229447..119233320, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (117671948..117676292, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (116912343..116916073, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486598 Neighboring gene uncharacterized LOC134486599 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134486600 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effect of antisense oligodeoxynucleotide for sepiapterin reductase on the viability of PC12 cells in the presence of exogenous carbonyl compounds. Fujimoto K, et al. Chem Biol Interact, 2003 Feb 1. PMID 12604243
    2. Immunological evidence for the requirement of sepiapterin reductase for tetrahydrobiopterin biosynthesis in brain. Levine RA, et al. J Neurochem, 1990 Apr. PMID 2179471
    3. Isolation and expression of rat liver sepiapterin reductase cDNA. Citron BA, et al. Proc Natl Acad Sci U S A, 1990 Aug. PMID 2201030, Free PMC Article
    4. The complete amino acid sequence of the mature form of rat sepiapterin reductase. Oyama R, et al. Biochem Biophys Res Commun, 1990 Dec 14. PMID 2260974
    5. Functionally important residues tyrosine-171 and serine-158 in sepiapterin reductase. Fujimoto K, et al. Biochim Biophys Acta, 1999 May 18. PMID 10350607

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ninety-six-hour starved peripheral blood mononuclear cell supernatant inhibited LA7 breast cancer stem cells induced tumor via reduction in angiogenesis and alternations in Gch1 and Spr expressions.
      Title: Ninety-six-hour starved peripheral blood mononuclear cell supernatant inhibited LA7 breast cancer stem cells induced tumor via reduction in angiogenesis and alternations in Gch1 and Spr expressions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sepiapterin reductase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sepiapterin reductase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sepiapterin reductase (NADP+) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-phenylalanine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within norepinephrine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pteridine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within serotonin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tetrahydrobiopterin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrahydrobiopterin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tetrahydrobiopterin biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within tetrahydrobiopterin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within voluntary musculoskeletal movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sepiapterin reductase
    Names
    sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
    NP_062054.1
    XP_038963128.1
    XP_038963129.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019181.2 → NP_062054.1  sepiapterin reductase

      See identical proteins and their annotated locations for NP_062054.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P18297
      UniProtKB/TrEMBL
      A0A8I5ZU80, B2RYK3
      Related
      ENSRNOP00000020749.4, ENSRNOT00000020749.8
      Conserved Domains (1) summary
      cl21454
      Location:9 → 261
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      119229447..119233320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107201.2 → XP_038963129.1  sepiapterin reductase isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:1 → 130
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_039107200.2 → XP_038963128.1  sepiapterin reductase isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:9 → 164
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18297.1 GenPept UniProtKB/Swiss-Prot:P18297

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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