Lox lysyl oxidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Loxprovided by RGD
Official Full Name: lysyl oxidaseprovided by RGD
Primary source: RGD:3015
See related: EnsemblRapid:ENSRNOG00000014426 AllianceGenome:RGD:3015
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rrg1; H-rev142
Summary: Enables copper ion binding activity and protein-lysine 6-oxidase activity. Involved in extracellular matrix organization; response to steroid hormone; and response to xenobiotic stimulus. Acts upstream of or within cell chemotaxis; platelet-derived growth factor receptor-beta signaling pathway; and protein oxidation. Located in extracellular matrix. Used to study abdominal aortic aneurysm; arteriosclerosis; coronary artery disease; coronary restenosis; and hypertension. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; colon adenocarcinoma; hypertension; and thoracic aortic aneurysm. Orthologous to human LOX (lysyl oxidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 228.0), Adrenal (RPKM 195.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (48162889..48175640, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (45964544..45977431, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (47500320..47577819, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LOX overexpression programming mediates the osteoclast mechanism of low peak bone mass in female offspring rats caused by pregnant dexamethasone exposure.
Title: LOX overexpression programming mediates the osteoclast mechanism of low peak bone mass in female offspring rats caused by pregnant dexamethasone exposure.
Elastic Laminar Reorganization Occurs with Outward Diameter Expansion during Collateral Artery Growth and Requires Lysyl Oxidase for Stabilization.
Title: Elastic Laminar Reorganization Occurs with Outward Diameter Expansion during Collateral Artery Growth and Requires Lysyl Oxidase for Stabilization.
Lysyl oxidase inhibits TNF-alpha induced rat nucleus pulposus cell apoptosis via regulating Fas/FasL pathway and the p53 pathways.
Title: Lysyl oxidase inhibits TNF-α induced rat nucleus pulposus cell apoptosis via regulating Fas/FasL pathway and the p53 pathways.
The data suggest that LOX may play an important role in the fibrosis of corpus cavernosum after ischemic priapism, and anti-LOX may be a novel target for patients suffering from ischemic priapism.
Title: Effect of lysyl oxidase (LOX) on corpus cavernous fibrosis caused by ischaemic priapism.
LOX over-activation contributes to penile fibrosis and LOX inhibition could be a promising strategy in preventing the progression of cavernous nerve injury-induced erectile dysfunction.
Title: Amelioration of Cavernosal Fibrosis and Erectile Function by Lysyl Oxidase Inhibition in a Rat Model of Cavernous Nerve Injury.
Overexpression of miR-30a contributes to the development of aortic dissection, possibly by targeting the expression of LOX.
Title: Overexpression of microRNA-30a contributes to the development of aortic dissection by targeting lysyl oxidase.
data suggest a detrimental role for the chronic increase of cardiac LOX expression and activity in the transition from compensated remodeling to decompensated failure.
Title: Detrimental role of lysyl oxidase in cardiac remodeling.
Together, these findings suggest that bone fragility in DM2 is initiated in the matrix phase and that the LOX family may play a critical part in the pathogenesis of DM2 mediated bone fragility.
Title: LOX-related collagen crosslink changes act as an initiator of bone fragility in a ZDF rats model.
The interaction of alpha2beta1 integrin to collagen I in the cellular microenvironment can regulate expression of LOX.
Title: Lysyl oxidase expression in cardiac fibroblasts is regulated by α2β1 integrin interactions with the cellular microenvironment.
Here we show that orthotopic implantation of rat prostate AT-1 tumour cells increased LOX and LOXLs mRNA expressions in the tumour and in the surrounding non-malignant prostate tissue
Title: Inhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has Tumour-Promoting and Tumour-Suppressing Roles in Experimental Prostate Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (41)

General gene information

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Markers

D18Got43 (e-PCR)
- UniSTS:115220

D18Got44 (e-PCR)
- UniSTS:113732

RH139210 (e-PCR)
- UniSTS:221296

RH134457 (e-PCR)
- UniSTS:217737

D18Chm55 (e-PCR)
- UniSTS:518322

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISS Inferred from Sequence or Structural Similarity more info
enables copper ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-lysine 6-oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine 6-oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-lysine 6-oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-lysine 6-oxidase activity	ISO Inferred from Sequence Orthology more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aorta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ascending aorta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to chemokine	ISO Inferred from Sequence Orthology more info
involved_in collagen fibril organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in collagen fibril organization	IDA Inferred from Direct Assay more info	PubMed
involved_in collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within collagen fibril organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within connective tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within descending aorta development	ISO Inferred from Sequence Orthology more info
involved_in elastic fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within elastic fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell cellular homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine oxidation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within platelet-derived growth factor receptor-beta signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of striated muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to steroid hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	ISO Inferred from Sequence Orthology more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein-lysine 6-oxidase

Names: Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts)

NP_001400932.1

EC 1.4.3.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001414003.1 → NP_001400932.1 protein-lysine 6-oxidase precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

P16636

UniProtKB/TrEMBL

A6IX14

Related

ENSRNOP00000019844.3, ENSRNOT00000019844.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

48162889..48175640 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_017061.2: Suppressed sequence

Description

NM_017061.2: This RefSeq was removed because currently there is insufficient support for the transcript.