C1qc complement C1q C chain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C1qcprovided by RGD
Official Full Name: complement C1q C chainprovided by RGD
Primary source: RGD:1306828
See related: AllianceGenome:RGD:1306828
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adib; C1qg
Summary: Predicted to be involved in complement activation, classical pathway; negative regulation of myeloid leukocyte differentiation; and synapse pruning. Located in synapse. Orthologous to human C1QC (complement C1q C chain). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 1714.5), Liver (RPKM 413.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (154410845..154414208, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (149127412..149130757, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (155255013..155258631, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that complement C1q expression may play a principal role in hepatic ischemia-reperfusion (I/R) injury, particularly at the early stage of perfusion.
Title: Effect of complement C1q expression on hepatic ischemia-reperfusion injury in rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133915 (e-PCR)
- UniSTS:217198

AA851367 (e-PCR)
- UniSTS:261610

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in complement activation, classical pathway	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of granulocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of granulocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in synapse pruning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
part_of complement component C1q complex	IEA Inferred from Electronic Annotation more info
part_of complement component C1q complex	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement C1q subcomponent subunit C

Names: adiponectin b; complement component 1, q subcomponent, C chain; complement component 1, q subcomponent, gamma polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008524.2 → NP_001008524.1 complement C1q subcomponent subunit C precursor

See identical proteins and their annotated locations for NP_001008524.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P31722, Q5RJZ8

UniProtKB/TrEMBL

A0A8I5ZWV4, A6ITC5

Conserved Domains (2) summary

smart00110
Location:114 → 245

C1Q; Complement component C1q domain

pfam01391
Location:34 → 82

Collagen; Collagen triple helix repeat (20 copies)