Mas1 MAS1 proto-oncogene, G protein-coupled receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mas1provided by RGD
Official Full Name: MAS1 proto-oncogene, G protein-coupled receptorprovided by RGD
Primary source: RGD:3049
See related: EnsemblRapid:ENSRNOG00000014971 AllianceGenome:RGD:3049
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mgra; c-mas
Summary: Predicted to enable angiotensin receptor activity and peptide binding activity. Involved in several processes, including hippocampus development; positive regulation of DNA replication; and regulation of phosphate metabolic process. Located in cell surface. Used to study glaucoma and hypertension. Biomarker of chronic kidney disease; congestive heart failure; dilated cardiomyopathy; and primary biliary cholangitis. Orthologous to human MAS1 (MAS1 proto-oncogene, G protein-coupled receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 15.2), Heart (RPKM 5.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (50428064..50459537)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (47879956..47911500)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (48076761..48108218)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G protein-coupled receptor MAS1 induces an inhibitory effect on myocardial infarction-induced myocardial injury.
Title: G protein-coupled receptor MAS1 induces an inhibitory effect on myocardial infarction-induced myocardial injury.
Aerobic training-mediated DNA hypermethylation of Agtr1a and Mas1 genes ameliorate mesenteric arterial function in spontaneously hypertensive rats.
Title: Aerobic training-mediated DNA hypermethylation of Agtr1a and Mas1 genes ameliorate mesenteric arterial function in spontaneously hypertensive rats.
Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor in Rat Polycystic Ovaries.
Title: Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor in Rat Polycystic Ovaries.
Mas Receptor Activation Contributes to the Improvement of Nitric Oxide Bioavailability and Vascular Remodeling During Chronic AT1R (Angiotensin Type-1 Receptor) Blockade in Experimental Hypertension.
Title: Mas Receptor Activation Contributes to the Improvement of Nitric Oxide Bioavailability and Vascular Remodeling During Chronic AT1R (Angiotensin Type-1 Receptor) Blockade in Experimental Hypertension.
Secreted Monocyte miR-27a, via Mesenteric Arterial Mas Receptor-eNOS Pathway, Causes Hypertension.
Title: Secreted Monocyte miR-27a, via Mesenteric Arterial Mas Receptor-eNOS Pathway, Causes Hypertension.
TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor.
Title: TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor.
Data support the hypothesis that interaction between AT1R and Mas1 contributes to proangiogenic Ang-(1-7) signaling in the skeletal muscle.
Title: Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats.
Ang-(1-7) stimulates beige markers and thermogenesis via the Mas receptor.
Title: Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor.
Small molecule ligands modulate numerous G protein-dependent and independent pathways through MAS1.
Title: Angiotensin (1-7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor.
Renal AT1 receptor activation, as well as Mas receptor activation, plays an essential role in mediating Ang-(1-7)-induced natriuresis and diuresis.
Title: Intrarenal Mas and AT(1) receptors play a role in mediating the excretory actions of renal interstitial angiotensin-(1-7) infusion in anaesthetized rats.

Submit: New GeneRIF Correction See all GeneRIFs (47)

General gene information

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Markers

BF386436 (e-PCR)
- UniSTS:243732

BB276039 (e-PCR)
- UniSTS:209271

BF414744 (e-PCR)
- UniSTS:248749

RH94551 (e-PCR)
- UniSTS:119799

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables angiotensin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables angiotensin receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to peptide hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA replication	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proto-oncogene Mas

Names: MAS proto-oncogene; MAS1 oncogene; Mas-related G protein-coupled receptor a; angiotensin-(1-7) receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012757.2 → NP_036889.1 proto-oncogene Mas

See identical proteins and their annotated locations for NP_036889.1

Status: VALIDATED

Source sequence(s)

BC078884

UniProtKB/Swiss-Prot

P12526

UniProtKB/TrEMBL

W8W3M4

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

50428064..50459537

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281329.1 → XP_063137399.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

P12526

UniProtKB/TrEMBL

W8W3M4

Related

ENSRNOP00000020100.4, ENSRNOT00000020100.7
XM_039101409.2 → XP_038957337.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

P12526

UniProtKB/TrEMBL

W8W3M4

Related

ENSRNOP00000097396.1, ENSRNOT00000104217.2

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063281319.1 → XP_063137389.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

P12526

UniProtKB/TrEMBL

W8W3M4
XM_063281307.1 → XP_063137377.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

P12526

UniProtKB/TrEMBL

W8W3M4
XM_006227860.5 → XP_006227922.1 proto-oncogene Mas isoform X1

See identical proteins and their annotated locations for XP_006227922.1

UniProtKB/Swiss-Prot

P12526

UniProtKB/TrEMBL

W8W3M4

Related

ENSRNOP00000104659.1, ENSRNOT00000132244.1

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_039101408.2 → XP_038957336.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

P12526

UniProtKB/TrEMBL

W8W3M4

Related

ENSRNOP00000103225.1, ENSRNOT00000164553.1

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063281318.1 → XP_063137388.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

P12526

UniProtKB/TrEMBL

W8W3M4
XM_039101416.2 → XP_038957344.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

P12526

UniProtKB/TrEMBL

W8W3M4

Related

ENSRNOP00000100641.1, ENSRNOT00000127520.1

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063281312.1 → XP_063137382.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

P12526

UniProtKB/TrEMBL

W8W3M4