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    Cox7a2l cytochrome c oxidase subunit 7A2 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298762, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cox7a2lprovided by RGD
    Official Full Name
    cytochrome c oxidase subunit 7A2 likeprovided by RGD
    Primary source
    RGD:1306111
    See related
    EnsemblRapid:ENSRNOG00000004526 AllianceGenome:RGD:1306111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Predicted to be located in mitochondrion and nucleolus. Predicted to be part of respiratory chain complex. Orthologous to human COX7A2L (cytochrome c oxidase subunit 7A2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 975.2), Thymus (RPKM 882.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cox7a2l in Genome Data Viewer
    Location:
    6q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (16936574..16950797)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (11184064..11198287)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (6695807..6709790, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479097 Neighboring gene uncharacterized LOC120093197 Neighboring gene uncharacterized LOC134479098 Neighboring gene EMAP like 4 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 10 Neighboring gene uncharacterized LOC102556624

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle. Ikeda K, et al. Nat Commun, 2013. PMID 23857330
    2. Supercomplex assembly determines electron flux in the mitochondrial electron transport chain. Lapuente-Brun E, et al. Science, 2013 Jun 28. PMID 23812712
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respirasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respirasome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of oxidative phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 7A2 like
    Names
    cytochrome c oxidase subunit VIIa polypeptide 2 like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106704.2 → NP_001100174.1  cytochrome c oxidase subunit 7A2 like isoform 1

      See identical proteins and their annotated locations for NP_001100174.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6H9M6, D3ZYX8
      Conserved Domains (1) summary
      cd00928
      Location:62 → 115
      Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    2. NM_001399338.1 → NP_001386267.1  cytochrome c oxidase subunit 7A2 like isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6GHX2

    3. NM_001399340.1 → NP_001386269.1  cytochrome c oxidase subunit 7A2 like isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AAY1, A0A8I6GHX2, B2RYT5
      Related
      ENSRNOP00000063344.2, ENSRNOT00000065464.4
      Conserved Domains (1) summary
      cd00928
      Location:55 → 108
      Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    4. NM_001399341.1 → NP_001386270.1  cytochrome c oxidase subunit 7A2 like isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AAY1, A0A8I6GHX2

    RNA

    1. NR_174177.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      Related
      ENSRNOT00000105892.2

    2. NR_174178.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    3. NR_174179.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    4. NR_174180.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    5. NR_174181.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      16936574..16950797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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