Serpinb3a serpin family B member 3A [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Serpinb3aprovided by RGD
Full Name: serpin family B member 3Aprovided by RGD
Primary source: RGD:1562868
See related: EnsemblRapid:ENSRNOG00000070387 AllianceGenome:RGD:1562868
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562868
Summary: Predicted to enable protease binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity and protection from natural killer cell mediated cytotoxicity. Predicted to be located in cytosol and plasma membrane. Predicted to be active in extracellular space. Orthologous to several human genes including SERPINB4 (serpin family B member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 95.7) and Thymus (RPKM 7.5) See more
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (23755690..23766188, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (23241303..23246328, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (27153500..27159319, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of peptidase activity	ISO Inferred from Sequence Orthology more info
involved_in protection from natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

Names: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain

XM_063272666.1 → XP_063128736.1 serpin B4-like

UniProtKB/TrEMBL

A0A8I6ADB0, A0A8I6AJJ4
XM_006249640.5 → XP_006249702.1 serpin B4-like

See identical proteins and their annotated locations for XP_006249702.1

UniProtKB/TrEMBL

A0A8I6ADB0, A0A8I6AJJ4

Related

ENSRNOP00000046632.4, ENSRNOT00000040021.4

Conserved Domains (1) summary

cl00137
Location:5 → 387

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...