Semg1 semenogelin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Semg1provided by RGD
Official Full Name: semenogelin 1provided by RGD
Primary source: RGD:3790
See related: EnsemblRapid:ENSRNOG00000013776 AllianceGenome:RGD:3790
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Svp1; Svs2; SVS2P; SVPIIA; Svs2p2; RATSVPIIA
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of flagellated sperm motility; positive regulation of serine-type endopeptidase activity; and sperm capacitation. Predicted to act upstream of or within fertilization. Predicted to be located in acrosomal vesicle and extracellular space. Predicted to be part of protein-containing complex. Orthologous to several human genes including SEMG1 (semenogelin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 3q42

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (173329413..173332261, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (152910033..152912882, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (160627609..160630457, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BI274477 (e-PCR)
- UniSTS:249094

D3Arb13 (e-PCR)
- UniSTS:239510

D1Bda73 (e-PCR)
- UniSTS:239824

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in coagulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fertilization	ISO Inferred from Sequence Orthology more info
involved_in mating plug formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sperm capacitation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: seminal vesicle secretory protein 2

Names: SVS II; semenogelin I; seminal vesicle protein, secretion 1; seminal vesicle protein, secretion 2; seminal vesicle secretory protein II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.