TJP2 tight junction protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TJP2provided by HGNC
Official Full Name: tight junction protein 2provided by HGNC
Primary source: HGNC:HGNC:11828
See related: Ensembl:ENSG00000119139 MIM:607709; AllianceGenome:HGNC:11828
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZO2; X104; FHCA1; PFIC4; DFNA51; DUP9q21.11; C9DUPq21.11
Summary: This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression: Ubiquitous expression in lung (RPKM 15.3), fat (RPKM 14.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q21.11

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (69121264..69255208)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (81294639..81423094)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (71736180..71870124)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP.
Title: p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP.
Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD.
Title: Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD.
TJP2 hepatobiliary disorders: Novel variants and clinical diversity.
Title: TJP2 hepatobiliary disorders: Novel variants and clinical diversity.
New tight junction protein 2 variant causing progressive familial intrahepatic cholestasis type 4 in adults: A case report.
Title: New tight junction protein 2 variant causing progressive familial intrahepatic cholestasis type 4 in adults: A case report.
Supra-molecular assembly and positioning of tight junctions as continuous networks of adhesion strands are dependent on the membrane-associated scaffolding proteins ZO1 and ZO2.
Title: Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions.
It is a potential target of miR-543.
Title: miR-543 promoted the cell proliferation and invasion of nasopharyngeal carcinoma by targeting the JAM-A.
Results suggested that a reduction in CLDN18-dependent ZO-2 expression enhances MMP2 expression in lung adenocarcinoma cells, resulting in the promotion of the cell migration.
Title: ZO-2 Suppresses Cell Migration Mediated by a Reduction in Matrix Metalloproteinase 2 in Claudin-18-Expressing Lung Adenocarcinoma A549 Cells.
Mutations in the genes responsible for PFIC may be involved in both young and adults with cryptogenic cholestasis in a considerable number of cases, including in heterozygous status.
Title: Cryptogenic cholestasis in young and adults: ATP8B1, ABCB11, ABCB4, and TJP2 gene variants analysis by high-throughput sequencing.
Biochemistry and microscopy approaches in T cells confirmed SNX27/ZO-2 PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 at the IS
Title: Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse.
A likely causal mutation was identified in the majority (61%), spanning many genes including ones that have only rarely been reported to cause cholestatic liver disease, e.g. TJP2 and VIPAS39
Title: Genetic profiling of children with advanced cholestatic liver disease.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Cholestasis, progressive familial intrahepatic, 4 MedGen: C2931067 OMIM: 615878 GeneReviews: Not available	Compare labs
Hypercholanemia, familial 1 MedGen: C5542604 OMIM: 607748 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Treatment of cultured human brain endothelial cells with HIV-1 gp120 results in increased permeability of the endothelial monolayer and causes disruption and downregulation of the tight junction proteins ZO-1, ZO-2, and occludin in these cells	PubMed
Tat	tat	Exposure of brain micro vascular endothelial cells to HIV-1 Tat results in a decrease of claudin-1, claudin-5, and zonula occludens-2 expression and cellular redistribution of claudin-5, suggesting potential disturbance of the blood-brain barrier by Tat	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9S1716 (e-PCR)
- UniSTS:20005

SHGC-132518 (e-PCR)
- UniSTS:173935

SGC30152 (e-PCR)
- UniSTS:39540

G54053 (e-PCR)
- UniSTS:109435

RH39762 (e-PCR)
- UniSTS:90538

SHGC-34170 (e-PCR)
- UniSTS:8110

SHGC-148426 (e-PCR)
- UniSTS:173003

D9S886 (e-PCR)
- UniSTS:148947

D9S744E (e-PCR)
- UniSTS:148968

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cadherin binding	HDA more info	PubMed
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GDP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in GMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of endothelial intestinal barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of endothelial intestinal barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in intestinal absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of blood-brain barrier permeability	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood-brain barrier permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell contact zone	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: tight junction protein ZO-2

Names: Friedreich ataxia region gene X104 (tight junction protein ZO-2); zona occludens 2; zonula occludens protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016342.2 RefSeqGene

Range

78371..159302

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1201

mRNA and Protein(s)

NM_001170414.2 → NP_001163885.1 tight junction protein ZO-2 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) has multiple differences, compared to variant 1. These differences include a distinct 5' UTR and translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.

Source sequence(s)

AA724570, AI738923, AK295016, CX865985, DA270962, DB196171

UniProtKB/TrEMBL

B7Z2R3

Related

ENSP00000496877.1, ENST00000647986.1

Conserved Domains (5) summary

cd12027
Location:581 → 643

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:677 → 856

GuKc; Guanylate kinase homologues

COG0265
Location:279 → 369

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:9 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:276 → 359

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001170415.1 → NP_001163886.1 tight junction protein ZO-2 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences include a distinct 5' UTR and translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AK302483, AL358113, DC325189

Consensus CDS

CCDS55315.1

UniProtKB/TrEMBL

A0A3B3ITE1

Related

ENSP00000442090.1, ENST00000535702.6

Conserved Domains (5) summary

cd12027
Location:608 → 670

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:704 → 883

GuKc; Guanylate kinase homologues

COG0265
Location:306 → 396

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:36 → 121

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:303 → 386

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001170416.2 → NP_001163887.1 tight junction protein ZO-2 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.

Source sequence(s)

AL358113

Consensus CDS

CCDS55316.1

UniProtKB/TrEMBL

A0A3B3ITE1

Related

ENSP00000438262.1, ENST00000539225.2

Conserved Domains (5) summary

cd12027
Location:635 → 697

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:731 → 910

GuKc; Guanylate kinase homologues

COG0265
Location:333 → 423

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:63 → 148

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:330 → 413

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001369870.1 → NP_001356799.1 tight junction protein ZO-2 isoform 6

Status: REVIEWED

Source sequence(s)

AL162730, AL358113, AL590238

UniProtKB/TrEMBL

A0A3B3ITE1

Conserved Domains (6) summary

cd12027
Location:579 → 641

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:675 → 854

GuKc; Guanylate kinase homologues

cd00992
Location:9 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR01622
Location:160 → 251

SF-CC1; splicing factor, CC1-like family

TIGR01642
Location:121 → 203

U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

pfam00595
Location:276 → 359

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001369871.1 → NP_001356800.1 tight junction protein ZO-2 isoform 7

Status: REVIEWED

Source sequence(s)

AL358113, AL590238

UniProtKB/TrEMBL

A0A3B3ITE1

Conserved Domains (6) summary

cd12027
Location:581 → 643

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:677 → 856

GuKc; Guanylate kinase homologues

cd00992
Location:9 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR01622
Location:160 → 251

SF-CC1; splicing factor, CC1-like family

TIGR01642
Location:121 → 203

U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

pfam00595
Location:276 → 359

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001369872.1 → NP_001356801.1 tight junction protein ZO-2 isoform 8

Status: REVIEWED

Source sequence(s)

AL358113

UniProtKB/TrEMBL

A0A3B3ISZ5

Related

ENSP00000497539.1, ENST00000649943.1

Conserved Domains (6) summary

cd12027
Location:604 → 666

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:700 → 879

GuKc; Guanylate kinase homologues

smart00228
Location:303 → 385

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:32 → 117

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR01622
Location:183 → 274

SF-CC1; splicing factor, CC1-like family

TIGR01642
Location:144 → 226

U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
NM_001369873.1 → NP_001356802.1 tight junction protein ZO-2 isoform 9

Status: REVIEWED

Source sequence(s)

AL358113

UniProtKB/TrEMBL

B7Z954

Conserved Domains (6) summary

cd12027
Location:604 → 666

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:700 → 879

GuKc; Guanylate kinase homologues

cd00992
Location:32 → 117

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR01622
Location:183 → 274

SF-CC1; splicing factor, CC1-like family

TIGR01642
Location:144 → 226

U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

pfam00595
Location:299 → 382

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001369874.1 → NP_001356803.1 tight junction protein ZO-2 isoform 10

Status: REVIEWED

Source sequence(s)

AL358113

Consensus CDS

CCDS94416.1

UniProtKB/TrEMBL

A0A3B3IU51, B7Z2R3

Related

ENSP00000498068.1, ENST00000649134.1

Conserved Domains (6) summary

cd12027
Location:608 → 670

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:704 → 883

GuKc; Guanylate kinase homologues

cd00992
Location:36 → 121

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR01622
Location:187 → 278

SF-CC1; splicing factor, CC1-like family

TIGR01642
Location:148 → 230

U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

pfam00595
Location:303 → 386

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001369875.1 → NP_001356804.1 tight junction protein ZO-2 isoform 11

Status: REVIEWED

Source sequence(s)

AL358113

UniProtKB/TrEMBL

A0A3B3ITE1

Related

ENSP00000497861.1, ENST00000650084.1

Conserved Domains (6) summary

cd12027
Location:608 → 670

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:704 → 883

GuKc; Guanylate kinase homologues

cd00992
Location:36 → 121

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR01622
Location:187 → 278

SF-CC1; splicing factor, CC1-like family

TIGR01642
Location:148 → 230

U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

pfam00595
Location:303 → 386

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_004817.4 → NP_004808.2 tight junction protein ZO-2 isoform 1

See identical proteins and their annotated locations for NP_004808.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform (1).

Source sequence(s)

AL358113, BC027592, DB090695, L27476

Consensus CDS

CCDS6627.1

UniProtKB/Swiss-Prot

A2A3H9, B7Z2R8, B7Z7T6, F5H301, F5H886, Q15883, Q5VXL0, Q5VXL1, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1, Q9UDY2

UniProtKB/TrEMBL

A0A3B3ITE1

Related

ENSP00000366453.4, ENST00000377245.9

Conserved Domains (5) summary

cd12027
Location:604 → 666

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:700 → 879

GuKc; Guanylate kinase homologues

COG0265
Location:302 → 392

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:32 → 117

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:299 → 382

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_201629.3 → NP_963923.1 tight junction protein ZO-2 isoform 2

See identical proteins and their annotated locations for NP_963923.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two in-frame exons in the 3' coding region, compared to variant (1). The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AA724570, AK295016, AK304447, AL358113, DB090695

Consensus CDS

CCDS6628.1

UniProtKB/TrEMBL

B7Z2R3

Related

ENSP00000345893.4, ENST00000348208.9

Conserved Domains (5) summary

cd12027
Location:604 → 666

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:700 → 879

GuKc; Guanylate kinase homologues

COG0265
Location:302 → 392

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:32 → 117

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:299 → 382

PDZ; PDZ domain (Also known as DHR or GLGF)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

69121264..69255208

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011519206.3 → XP_011517508.1 tight junction protein ZO-2 isoform X1

See identical proteins and their annotated locations for XP_011517508.1

UniProtKB/TrEMBL

A0A3B3ITE1

Conserved Domains (6) summary

cd12027
Location:581 → 643

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:677 → 856

GuKc; Guanylate kinase homologues

cd00992
Location:9 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR01622
Location:160 → 251

SF-CC1; splicing factor, CC1-like family

TIGR01642
Location:121 → 203

U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

pfam00595
Location:276 → 359

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_011519208.3 → XP_011517510.1 tight junction protein ZO-2 isoform X1

See identical proteins and their annotated locations for XP_011517510.1

UniProtKB/TrEMBL

A0A3B3ITE1

Conserved Domains (6) summary

cd12027
Location:581 → 643

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:677 → 856

GuKc; Guanylate kinase homologues

cd00992
Location:9 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR01622
Location:160 → 251

SF-CC1; splicing factor, CC1-like family

TIGR01642
Location:121 → 203

U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

pfam00595
Location:276 → 359

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_047424090.1 → XP_047280046.1 tight junction protein ZO-2 isoform X1

UniProtKB/TrEMBL

A0A3B3ITE1
XM_047424095.1 → XP_047280051.1 tight junction protein ZO-2 isoform X2

UniProtKB/TrEMBL

A0A3B3ITE1
XM_047424091.1 → XP_047280047.1 tight junction protein ZO-2 isoform X1

UniProtKB/TrEMBL

A0A3B3ITE1
XM_011519207.3 → XP_011517509.1 tight junction protein ZO-2 isoform X1

See identical proteins and their annotated locations for XP_011517509.1

UniProtKB/TrEMBL

A0A3B3ITE1

Related

ENSP00000489860.1, ENST00000636438.1

Conserved Domains (6) summary

cd12027
Location:581 → 643

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:677 → 856

GuKc; Guanylate kinase homologues

cd00992
Location:9 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR01622
Location:160 → 251

SF-CC1; splicing factor, CC1-like family

TIGR01642
Location:121 → 203

U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

pfam00595
Location:276 → 359

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_047424092.1 → XP_047280048.1 tight junction protein ZO-2 isoform X1

UniProtKB/TrEMBL

A0A3B3ITE1
XM_011519209.3 → XP_011517511.1 tight junction protein ZO-2 isoform X1

See identical proteins and their annotated locations for XP_011517511.1

UniProtKB/TrEMBL

A0A3B3ITE1

Conserved Domains (6) summary

cd12027
Location:581 → 643

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:677 → 856

GuKc; Guanylate kinase homologues

cd00992
Location:9 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR01622
Location:160 → 251

SF-CC1; splicing factor, CC1-like family

TIGR01642
Location:121 → 203

U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

pfam00595
Location:276 → 359

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_047424094.1 → XP_047280050.1 tight junction protein ZO-2 isoform X1

UniProtKB/TrEMBL

A0A3B3ITE1

Alternate T2T-CHM13v2.0

Genomic

NC_060933.1 Alternate T2T-CHM13v2.0

Range

81294639..81423094

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054364197.1 → XP_054220172.1 tight junction protein ZO-2 isoform X1

UniProtKB/TrEMBL

A0A3B3ITE1
XM_054364195.1 → XP_054220170.1 tight junction protein ZO-2 isoform X1

UniProtKB/TrEMBL

A0A3B3ITE1
XM_054364196.1 → XP_054220171.1 tight junction protein ZO-2 isoform X1

UniProtKB/TrEMBL

A0A3B3ITE1
XM_054364202.1 → XP_054220177.1 tight junction protein ZO-2 isoform X2

UniProtKB/TrEMBL

A0A3B3ITE1
XM_054364194.1 → XP_054220169.1 tight junction protein ZO-2 isoform X1

UniProtKB/TrEMBL

A0A3B3ITE1
XM_054364198.1 → XP_054220173.1 tight junction protein ZO-2 isoform X1

UniProtKB/TrEMBL

A0A3B3ITE1
XM_054364200.1 → XP_054220175.1 tight junction protein ZO-2 isoform X1

UniProtKB/TrEMBL

A0A3B3ITE1
XM_054364199.1 → XP_054220174.1 tight junction protein ZO-2 isoform X1

UniProtKB/TrEMBL

A0A3B3ITE1
XM_054364201.1 → XP_054220176.1 tight junction protein ZO-2 isoform X1

UniProtKB/TrEMBL

A0A3B3ITE1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001170630.1: Suppressed sequence

Description

NM_001170630.1: This RefSeq was removed because currently there is insufficient support for the transcript.