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    Nab1 Ngfi-A binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64824, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nab1provided by RGD
    Official Full Name
    Ngfi-A binding protein 1provided by RGD
    Primary source
    RGD:70882
    See related
    EnsemblRapid:ENSRNOG00000012959 AllianceGenome:RGD:70882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within endochondral ossification; nervous system development; and regulation of epidermis development. Predicted to be active in nucleus. Orthologous to human NAB1 (NGFI-A binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 141.6), Heart (RPKM 87.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nab1 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (56545547..56585045)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (49053579..49093078)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (53906073..53945474)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene developmental pluripotency-associated protein 3-like Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Basal EGR-1 (zif268, NGFI-A, Krox-24) expression in developing striatal patches: role of dopamine and glutamate. Snyder-Keller A, et al. Brain Res, 2002 Dec 27. PMID 12470865
    2. Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain. Swirnoff AH, et al. Mol Cell Biol, 1998 Jan. PMID 9418898, Free PMC Article
    3. Active gene repression by the Egr2.NAB complex during peripheral nerve myelination. Mager GM, et al. J Biol Chem, 2008 Jun 27. PMID 18456662, Free PMC Article
    4. Nab proteins are essential for peripheral nervous system myelination. Le N, et al. Nat Neurosci, 2005 Jul. PMID 16136673
    5. Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. Russo MW, et al. Proc Natl Acad Sci U S A, 1995 Jul 18. PMID 7624335, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Egr2 directly represses genes during myelination in conjunction with NAB corepressors
      Title: Active gene repression by the Egr2.NAB complex during peripheral nerve myelination.
    2. NGFI-A protein expression in the developing striatum appears to be driven first by dopaminergic afferents, and then later in development by excitatory glutamatergic afferents.
      Title: Basal EGR-1 (zif268, NGFI-A, Krox-24) expression in developing striatal patches: role of dopamine and glutamate.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Schwann cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endochondral ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of epidermis development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NGFI-A-binding protein 1
    Names
    EGR-1-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022856.5 → NP_074047.2  NGFI-A-binding protein 1

      See identical proteins and their annotated locations for NP_074047.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q62722
      UniProtKB/TrEMBL
      A0A8I5XW60, A6INW5
      Related
      ENSRNOP00000077471.1, ENSRNOT00000106868.2
      Conserved Domains (3) summary
      pfam04902
      Location:321 → 484
      Nab1; Conserved region in Nab1
      pfam04904
      Location:5 → 83
      NCD1; NAB conserved region 1 (NCD1)
      pfam04905
      Location:190 → 316
      NCD2; NAB conserved region 2 (NCD2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      56545547..56585045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084187.2 → XP_038940115.1  NGFI-A-binding protein 1 isoform X2

      Conserved Domains (2) summary
      pfam04904
      Location:5 → 83
      NCD1; NAB conserved region 1 (NCD1)
      pfam04905
      Location:190 → 273
      NCD2; NAB conserved region 2 (NCD2)

    2. XM_039084185.2 → XP_038940113.1  NGFI-A-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q62722
      UniProtKB/TrEMBL
      A0A8I5XW60, A6INW5
      Conserved Domains (3) summary
      pfam04902
      Location:321 → 484
      Nab1; Conserved region in Nab1
      pfam04904
      Location:5 → 83
      NCD1; NAB conserved region 1 (NCD1)
      pfam04905
      Location:190 → 316
      NCD2; NAB conserved region 2 (NCD2)

    3. XM_039084186.2 → XP_038940114.1  NGFI-A-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q62722
      UniProtKB/TrEMBL
      A0A8I5XW60, A6INW5
      Related
      ENSRNOP00000017813.5, ENSRNOT00000017813.9
      Conserved Domains (3) summary
      pfam04902
      Location:321 → 484
      Nab1; Conserved region in Nab1
      pfam04904
      Location:5 → 83
      NCD1; NAB conserved region 1 (NCD1)
      pfam04905
      Location:190 → 316
      NCD2; NAB conserved region 2 (NCD2)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62722.2 GenPept UniProtKB/Swiss-Prot:Q62722

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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