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    Inpp4a inositol polyphosphate-4-phosphatase type I A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 80849, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Inpp4aprovided by RGD
    Official Full Name
    inositol polyphosphate-4-phosphatase type I Aprovided by RGD
    Primary source
    RGD:68386
    See related
    EnsemblRapid:ENSRNOG00000017660 AllianceGenome:RGD:68386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Predicted to be involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Predicted to be located in nuclear membrane; nucleoplasm; and postsynaptic density. Predicted to be active in cytoplasm and glutamatergic synapse. Orthologous to human INPP4A (inositol polyphosphate-4-phosphatase type I A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 219.4), Thymus (RPKM 113.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Inpp4a in Genome Data Viewer
    Location:
    9q21
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (47024064..47142391)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (39528245..39650574)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (43889887..44006593)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cyclic nucleotide gated channel subunit alpha 3 Neighboring gene CB1 cannabinoid receptor-interacting protein 1-like Neighboring gene cytochrome C oxidase assembly factor 5 Neighboring gene unc-50 inner nuclear membrane RNA binding protein Neighboring gene uncharacterized LOC120094669 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel nuclear translocation of inositol polyphosphate 4-phosphatase is associated with cell cycle, proliferation and survival. Chaudhuri R, et al. Biochim Biophys Acta Mol Cell Res, 2018 Jul 30. PMID 30071275
    2. The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Sasaki J, et al. Nature, 2010 May 27. PMID 20463662
    3. The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. Norris FA, et al. J Biol Chem, 1995 Jul 7. PMID 7608176
    4. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables inositol-1,3,4-trisphosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-3,4-bisphosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inositol polyphosphate-4-phosphatase type I A
    Names
    inositol polyphosphate 4-phosphatase type I
    inositol polyphosphate-4-phosphatase, type 1
    inositol polyphosphate-4-phosphatase, type I, 107kD
    type I inositol 3,4-bisphosphate 4-phosphatase
    NP_112264.4
    XP_038940152.1
    XP_038940153.1
    XP_038940154.1
    XP_038940156.1
    XP_038940157.1
    XP_038940158.1
    XP_038940161.1
    XP_038940162.1
    XP_038940164.1
    XP_038940166.1
    XP_038940168.1
    XP_038940169.1
    XP_063123836.1
    XP_063123838.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031002.4 → NP_112264.4  inositol polyphosphate-4-phosphatase type I A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q62784
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      47024064..47142391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084233.2 → XP_038940161.1  inositol polyphosphate-4-phosphatase type I A isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZYR7, A0A8I6ACW4
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    2. XM_063267766.1 → XP_063123836.1  inositol polyphosphate-4-phosphatase type I A isoform X7

      UniProtKB/TrEMBL
      A0A8I6ACW4

    3. XM_039084241.2 → XP_038940169.1  inositol polyphosphate-4-phosphatase type I A isoform X12

      UniProtKB/TrEMBL
      A0A8I6A0Y3
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    4. XM_039084224.2 → XP_038940152.1  inositol polyphosphate-4-phosphatase type I A isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACW4
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    5. XM_063267768.1 → XP_063123838.1  inositol polyphosphate-4-phosphatase type I A isoform X11

      UniProtKB/TrEMBL
      A0A8I6A0Y3

    6. XM_039084225.2 → XP_038940153.1  inositol polyphosphate-4-phosphatase type I A isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACW4
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    7. XM_039084230.2 → XP_038940158.1  inositol polyphosphate-4-phosphatase type I A isoform X4

      UniProtKB/TrEMBL
      A0A8I6ACW4
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    8. XM_039084238.2 → XP_038940166.1  inositol polyphosphate-4-phosphatase type I A isoform X9

      UniProtKB/Swiss-Prot
      Q62784
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    9. XM_039084240.2 → XP_038940168.1  inositol polyphosphate-4-phosphatase type I A isoform X10

      UniProtKB/Swiss-Prot
      Q62784
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    10. XM_039084226.2 → XP_038940154.1  inositol polyphosphate-4-phosphatase type I A isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACW4
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    11. XM_039084229.2 → XP_038940157.1  inositol polyphosphate-4-phosphatase type I A isoform X3

      UniProtKB/TrEMBL
      A0A8I6ACW4
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    12. XM_039084234.2 → XP_038940162.1  inositol polyphosphate-4-phosphatase type I A isoform X6

      UniProtKB/Swiss-Prot
      Q62784
      UniProtKB/TrEMBL
      D3ZBL5
      Related
      ENSRNOP00000024330.8, ENSRNOT00000024330.10
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    13. XM_039084236.2 → XP_038940164.1  inositol polyphosphate-4-phosphatase type I A isoform X8

      UniProtKB/TrEMBL
      A0A8I6A0Y3
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    14. XM_039084228.2 → XP_038940156.1  inositol polyphosphate-4-phosphatase type I A isoform X2

      UniProtKB/TrEMBL
      A0A8I6ACW4
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    RNA

    1. XR_005488970.2 RNA Sequence

    2. XR_005488971.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62784.1 GenPept UniProtKB/Swiss-Prot:Q62784

    Gene LinkOut

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