Ptgfr prostaglandin F receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptgfrprovided by RGD
Official Full Name: prostaglandin F receptorprovided by RGD
Primary source: RGD:3436
See related: EnsemblRapid:ENSRNOG00000046468 AllianceGenome:RGD:3436
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PF2AR
Summary: Predicted to enable prostaglandin F receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to prostaglandin D stimulus; and response to estradiol. Predicted to act upstream of or within negative regulation of apoptotic process and response to lipopolysaccharide. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in plasma membrane. Orthologous to human PTGFR (prostaglandin F receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 285.1), Liver (RPKM 73.0) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q45

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (243390820..243426647, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (240731185..240766674, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (257005813..257039036, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prostaglandin F-receptor antagonist AS604872 exacerbates vascular inflammation in hypertensive animals, facilitating intracranial aneurysm formation and aortic dissection.
Title: Exacerbation of intracranial aneurysm and aortic dissection in hypertensive rat treated with the prostaglandin F-receptor antagonist AS604872.
There was an increase rat prostaglandin F receptor expression in rat uterus with advancing gestation, a marked elevation of expression at term, and a concominant decrease during the postpartum period.
Title: Prostaglandin F receptor expression in intrauterine tissues of pregnant rats.
Data found that FP localizes in neuronal somata and dendrites but not in ependymal cells, tanycytes, or endothelial cells. Immunohistochemical analysis of serial sections showed the colocalization of FP and PGFS I.
Title: Colocalization of prostaglandin F(2alpha) receptor FP and prostaglandin F synthase-I in the spinal cord.
Activity of PGF(2alpha) by putative pacemaker cells underlies the generation of calcium action potentials in normal rat kidney monolayers.
Title: Role of the prostanoid FP receptor in action potential generation and phenotypic transformation of NRK fibroblasts.
NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha.
Title: NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha.

Submit: New GeneRIF Correction

General gene information

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Markers

AI059834 (e-PCR)
- UniSTS:244573

RH94482 (e-PCR)
- UniSTS:119730

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables prostaglandin F receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin F receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to prostaglandin D stimulus	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostaglandin F2-alpha receptor

Names: PGF receptor; PGF2-alpha receptor; prostanoid FP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013115.2 → NP_037247.1 prostaglandin F2-alpha receptor

See identical proteins and their annotated locations for NP_037247.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P43118, Q62787

UniProtKB/TrEMBL

A6HWJ3

Related

ENSRNOP00000065253.1, ENSRNOT00000071195.3

Conserved Domains (1) summary

cd15145
Location:27 → 316

7tmA_FP; prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

243390820..243426647 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233486.5 → XP_006233548.1 prostaglandin F2-alpha receptor isoform X1

See identical proteins and their annotated locations for XP_006233548.1

UniProtKB/Swiss-Prot

P43118, Q62787

UniProtKB/TrEMBL

A6HWJ3

Conserved Domains (1) summary

cd15145
Location:27 → 316

7tmA_FP; prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006233487.5 → XP_006233549.1 prostaglandin F2-alpha receptor isoform X1

See identical proteins and their annotated locations for XP_006233549.1

UniProtKB/Swiss-Prot

P43118, Q62787

UniProtKB/TrEMBL

A6HWJ3

Conserved Domains (1) summary

cd15145
Location:27 → 316

7tmA_FP; prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors