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    Atp5pf ATP synthase peripheral stalk subunit F6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94271, updated on 9-Dec-2024

    Summary

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    Symbol
    Atp5pfprovided by RGD
    Full Name
    ATP synthase peripheral stalk subunit F6provided by RGD
    Primary source
    RGD:621376
    See related
    EnsemblRapid:ENSRNOG00000001551 AllianceGenome:RGD:621376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atp5j
    Summary
    Contributes to ATP hydrolysis activity. Involved in several processes, including negative regulation of icosanoid secretion; positive regulation of heart rate; and response to muscle activity. Located in cell surface and extracellular space. Part of proton-transporting ATP synthase complex, coupling factor F(o). Used to study pulmonary hypertension. Biomarker of pulmonary hypertension. Orthologous to human ATP5PF (ATP synthase peripheral stalk subunit F6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 560.0), Muscle (RPKM 333.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp5pf in Genome Data Viewer
    Location:
    11q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (37368045..37375721, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (23881594..23889581, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (24286806..24294419, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene junctional adhesion molecule 2 Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene uncharacterized LOC134480962 Neighboring gene amyloid beta precursor protein Neighboring gene cysteine and tyrosine rich 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Comparison of gene and protein expressions in rats residing in standard cages with those having access to an exercise wheel. Alessio HM, et al. Biomed Res Int, 2014. PMID 24719897, Free PMC Article
    2. Circulating coupling factor 6 in human hypertension: role of reactive oxygen species. Osanai T, et al. J Hypertens, 2003 Dec. PMID 14654753
    3. Total synthesis of human and rat coupling factor-6 amide and pressor effects in the rat. Chang JK, et al. Regul Pept, 2003 May 15. PMID 12686462
    4. Mitochondrial coupling factor 6 as a potent endogenous vasoconstrictor. Osanai T, et al. J Clin Invest, 2001 Oct. PMID 11581303, Free PMC Article
    5. Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats. Osanai T, et al. J Hypertens, 2009 Sep. PMID 19474762

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CF6 shRNA effectively inhibited CF6 expression, abolished lung macrophage infiltration, reversed endothelial dysfunction and vascular remodeling, and ameliorated the severity of pulmonary hypertension and right ventricular dysfunction at 4 weeks both as a pretreatment and rescue intervention
      Title: Lung-specific RNA interference of coupling factor 6, a novel peptide, attenuates pulmonary arterial hypertension in rats.
    2. plasma level increased markedly during pathogenesis of pulmonary arterial hypertension (PAH), indicating that CF6 may be involved in the development of PAH
      Title: Coupling Factor 6 Is Upregulated in Monocrotaline-induced Pulmonary Arterial Hypertension in Rats.
    3. CF6 protein was upregulated in cardiac hypertrophy induced by hypertension; further mechanisms involved in this process should be investigated.
      Title: Mitochondrial coupling factor 6 upregulation in hypertension-induced cardiac hypertrophy.
    4. suppresses prostacyclin generation in resistance arteriole vascular smooth muscle cells, which is enhanced in spontaneously hypertensive rats by the overproduction of CF6 and the hyperresponsiveness to CF6
      Title: Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of arachidonate secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of prostaglandin secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of prostaglandin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of heart rate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to muscle activity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in substantia nigra development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting ATP synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase-coupling factor 6, mitochondrial
    Names
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6
    ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
    ATPase subunit F6
    coupling factor 6
    NP_446054.1
    XP_008766825.1
    XP_017453574.1
    XP_017453575.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428996.1 → NP_001415925.1  ATP synthase-coupling factor 6, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P21571
      UniProtKB/TrEMBL
      A6JL59

    2. NM_001428997.1 → NP_001415926.1  ATP synthase-coupling factor 6, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P21571
      UniProtKB/TrEMBL
      A6JL59

    3. NM_053602.2 → NP_446054.1  ATP synthase-coupling factor 6, mitochondrial precursor

      See identical proteins and their annotated locations for NP_446054.1

      Status: PROVISIONAL

      Source sequence(s)
      X54510
      UniProtKB/Swiss-Prot
      P21571
      UniProtKB/TrEMBL
      A6JL59
      Conserved Domains (1) summary
      pfam05511
      Location:1 → 96
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      37368045..37375721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598085.3 → XP_017453574.1  ATP synthase-coupling factor 6, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam05511
      Location:1 → 96
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

    2. XM_017598086.3 → XP_017453575.2  ATP synthase-coupling factor 6, mitochondrial isoform X1

      Related
      ENSRNOP00000002116.3, ENSRNOT00000002116.6

    3. XM_008768603.3 → XP_008766825.1  ATP synthase-coupling factor 6, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam05511
      Location:1 → 96
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21571.1 GenPept UniProtKB/Swiss-Prot:P21571

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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