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    Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79243, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hsd17b2provided by RGD
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 2provided by RGD
    Primary source
    RGD:621803
    See related
    EnsemblRapid:ENSRNOG00000013982 AllianceGenome:RGD:621803
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Involved in bone development; cellular response to metal ion; and steroid hormone biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 603.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hsd17b2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (62662320..62733944)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (45753576..45825203)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (50246404..50317892)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene phospholipase C, gamma 2 Neighboring gene uncharacterized LOC120098492 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 Neighboring gene M phase phosphoprotein 6 Neighboring gene small nucleolar RNA SNORA51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gestational protein restriction reduces expression of Hsd17b2 in rat placental labyrinth. Gao H, et al. Biol Reprod, 2012 Sep. PMID 22837477, Free PMC Article
    2. Aging reduces the efficacy of estrogen substitution to attenuate cardiac hypertrophy in female spontaneously hypertensive rats. Jazbutyte V, et al. Hypertension, 2006 Oct. PMID 16940216
    3. Cloning of rat 17 beta-hydroxysteroid dehydrogenase type 2 and characterization of tissue distribution and catalytic activity of rat type 1 and type 2 enzymes. Akinola LA, et al. Endocrinology, 1996 May. PMID 8612487
    4. Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity. Wu L, et al. J Biol Chem, 1993 Jun 15. PMID 8099587
    5. Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats. Banu SK, et al. Toxicol Appl Pharmacol, 2008 Oct 15. PMID 18602937

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gestational protein restriction reduces expression of Hsd17b2 in rat placental labyrinth.
      Title: Gestational protein restriction reduces expression of Hsd17b2 in rat placental labyrinth.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables testosterone dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables testosterone dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables testosterone dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in androgen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in androgen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in androgen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bone development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to metal ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in estrogen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in estrogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in estrogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in placenta development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within placenta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    estradiol 17-beta-dehydrogenase 2
    Names
    17-beta-HSD 2
    17-beta-hydroxysteroid dehydrogenase 2
    17-beta-hydroxysteroid dehydrogenase type 2
    testosterone 17-beta-dehydrogenase
    NP_077367.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024391.2 → NP_077367.2  estradiol 17-beta-dehydrogenase 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q62730
      UniProtKB/TrEMBL
      F7EZ71, Q5I0N4
      Related
      ENSRNOP00000018795.2, ENSRNOT00000018795.5
      Conserved Domains (1) summary
      cd09805
      Location:84 → 364
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      62662320..62733944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62730.1 GenPept UniProtKB/Swiss-Prot:Q62730

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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