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    Art2b ADP-ribosyltransferase 2b [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293152, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Art2bprovided by RGD
    Official Full Name
    ADP-ribosyltransferase 2bprovided by RGD
    Primary source
    RGD:3521
    See related
    EnsemblRapid:ENSRNOG00000019687 AllianceGenome:RGD:3521
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LY2; Rt6; Ag-F; Art2; Ly-2; PtaA; ARTC2; Art2a; RT6.1; RT6.2
    Summary
    Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity and hydrolase activity, acting on glycosyl bonds. Predicted to be involved in NAD catabolic process. Predicted to be located in plasma membrane and side of membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 89.3), Thymus (RPKM 44.3) and 2 other tissues See more
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    Genomic context

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    See Art2b in Genome Data Viewer
    Location:
    1q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (165368623..165386280, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (155956601..155974252, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (166665029..166685097, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097347 Neighboring gene phosphodiesterase 2A Neighboring gene microRNA 139 Neighboring gene uncharacterized LOC120099897 Neighboring gene lactate dehydrogenase A, pseudogene 3 Neighboring gene ClpB family mitochondrial disaggregase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose). Morrison AR, et al. J Biol Chem, 2006 Nov 3. PMID 16931513
    2. Regulatory role of arginine 204 in the catalytic activity of rat alloantigens ART2a and ART2b. Stevens LA, et al. J Biol Chem, 2003 May 30. PMID 12649291
    3. Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat. Mueller-Dieckmann C, et al. J Mol Biol, 2002 Sep 27. PMID 12270706
    4. Independent integration of rodent identifier (ID) elements into orthologous sites of some RT6 alleles of Rattus norvegicus and Rattus rattus. Rothenburg S, et al. J Mol Evol, 2002 Sep. PMID 12187378
    5. Expression, purification, crystallization and preliminary X-ray analysis of rat ecto-ADP-ribosyltransferase 2 (ART2.2). Mueller-Dieckmann C, et al. Acta Crystallogr D Biol Crystallogr, 2002 Jul. PMID 12077446

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression, purification, crystallization and X-ray analysis
      Title: Expression, purification, crystallization and preliminary X-ray analysis of rat ecto-ADP-ribosyltransferase 2 (ART2.2).
    2. Our data indicate that the RT6 alleles diverged about 1 myr ago and that the ID element integrated into the RT6a locus soon after this.
      Title: Independent integration of rodent identifier (ID) elements into orthologous sites of some RT6 alleles of Rattus norvegicus and Rattus rattus.
    3. capability of polymerizing ADP-ribose may not be unique to poly(ADP-ribose) polymerases and that poly(ADP-ribosylation), an established nuclear activity, may occur extracellularly and modulate cell function
      Title: ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).
    4. Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat.
      Title: Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC116041

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+-protein-arginine ADP-ribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-cell ecto-ADP-ribosyltransferase 2
    Names
    ADP-ribosyltransferase 2
    ADP-ribosyltransferase 2a
    ADP-ribosyltransferase C2 and C3 toxin-like 2
    Cell surface alloantigen peripheral T-cell antigen
    NAD(+) glycohydrolase
    T cell differentiation marker RT6.1
    T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 1
    T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 2
    T-cell ecto-ADP-ribosyltransferase 1
    T-cell mono(ADP-ribosyl)transferase 1
    T-cell mono(ADP-ribosyl)transferase 2
    T-cell surface protein Rt6.1
    T-cell surface protein Rt6.2
    alloantigen Rt6.1
    alloantigen Rt6.2
    cell surface alloantigen 6
    mono(ADP-ribosyl)transferase 2A
    mono(ADP-ribosyl)transferase 2B
    NP_942030.1
    XP_017444448.1
    XP_038962041.1
    XP_063141259.1
    XP_063141264.1
    XP_063141266.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198735.3 → NP_942030.1  T-cell ecto-ADP-ribosyltransferase 2 precursor

      See identical proteins and their annotated locations for NP_942030.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P17982, P20974, P97912, Q4FZV8, Q95576, Q9EPH9
      UniProtKB/TrEMBL
      A6I6V2
      Related
      ENSRNOP00000069125.1, ENSRNOT00000087792.3
      Conserved Domains (1) summary
      pfam01129
      Location:27 → 239
      ART; NAD:arginine ADP-ribosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      165368623..165386280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285189.1 → XP_063141259.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X1

      UniProtKB/Swiss-Prot
      P17982
      UniProtKB/TrEMBL
      A0A0G2JUJ8

    2. XM_017588959.3 → XP_017444448.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X2

      UniProtKB/Swiss-Prot
      P17982, P20974, P97912, Q4FZV8, Q95576, Q9EPH9
      UniProtKB/TrEMBL
      A6I6V2
      Conserved Domains (1) summary
      pfam01129
      Location:27 → 239
      ART; NAD:arginine ADP-ribosyltransferase

    3. XM_039106113.2 → XP_038962041.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X2

      UniProtKB/Swiss-Prot
      P17982, P20974, P97912, Q4FZV8, Q95576, Q9EPH9
      UniProtKB/TrEMBL
      A6I6V2
      Conserved Domains (1) summary
      pfam01129
      Location:27 → 239
      ART; NAD:arginine ADP-ribosyltransferase

    4. XM_063285196.1 → XP_063141266.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X2

      UniProtKB/Swiss-Prot
      P17982, P20974, P97912, Q4FZV8, Q95576, Q9EPH9
      UniProtKB/TrEMBL
      A6I6V2

    5. XM_063285194.1 → XP_063141264.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X2

      UniProtKB/Swiss-Prot
      P17982, P20974, P97912, Q4FZV8, Q95576, Q9EPH9
      UniProtKB/TrEMBL
      A6I6V2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17982.1 GenPept UniProtKB/Swiss-Prot:P17982
    P20974.2 GenPept UniProtKB/Swiss-Prot:P20974

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