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    Zmat3 zinc finger, matrin type 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64394, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zmat3provided by RGD
    Official Full Name
    zinc finger, matrin type 3provided by RGD
    Primary source
    RGD:620134
    See related
    EnsemblRapid:ENSRNOG00000063864 AllianceGenome:RGD:620134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wig1; PAG608
    Summary
    Predicted to enable RNA binding activity and zinc ion binding activity. Involved in positive regulation of apoptotic process. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human ZMAT3 (zinc finger matrin-type 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 73.6), Adrenal (RPKM 37.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zmat3 in Genome Data Viewer
    Location:
    2q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (117034517..117066141, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (115106046..115136888, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (118715229..118746109, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Specific induction of PAG608 in cranial and spinal motor neurons of L-DOPA-treated parkinsonian rats. Shimizu M, et al. Neurosci Res, 2008 Apr. PMID 18242749
    2. Suppression of p53-activated gene, PAG608, attenuates methamphetamine-induced neurotoxicity. Asanuma M, et al. Neurosci Lett, 2007 Mar 13. PMID 17234339
    3. A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis. Israeli D, et al. EMBO J, 1997 Jul 16. PMID 9250682, Free PMC Article
    4. The p53-activated gene, PAG608, requires a zinc finger domain for nuclear localization and oxidative stress-induced apoptosis. Higashi Y, et al. J Biol Chem, 2002 Nov 1. PMID 12196512
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The specific induction of PAG608 6-48h after L-DOPA injection in the extrapyramidal tracts, pyramidal tracts and corresponding lower motor neurons of the spinal cords suggests its involvement in molecular events in stimulated motor neurons.
      Title: Specific induction of PAG608 in cranial and spinal motor neurons of L-DOPA-treated parkinsonian rats.
    2. PAG608 may induce or regulate p53 expression and translocate to the nucleus and nucleolus using its first zinc finger domain during oxidative stress-induced apoptosis of catecholamine-containing cells.
      Title: The p53-activated gene, PAG608, requires a zinc finger domain for nuclear localization and oxidative stress-induced apoptosis.
    3. Methamphetamine neurotoxicity in monoaminergic cells is related, at least in part, to induction of PAG608 expression.
      Title: Suppression of p53-activated gene, PAG608, attenuates methamphetamine-induced neurotoxicity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger matrin-type protein 3
    Names
    p53 target zinc finger protein
    p53-activated gene 608 protein
    wild-type p53-induced gene 1
    zinc finger protein WIG-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022548.3 → NP_071993.1  zinc finger matrin-type protein 3

      See identical proteins and their annotated locations for NP_071993.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      O08781
      UniProtKB/TrEMBL
      A0A8I6GFU9, A6IHN5
      Related
      ENSRNOP00000087283.2, ENSRNOT00000103680.2
      Conserved Domains (2) summary
      smart00451
      Location:67 → 101
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:72 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      117034517..117066141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282482.1 → XP_063138552.1  zinc finger matrin-type protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GFU9, A0A8L2Q6J0

    2. XM_063282485.1 → XP_063138555.1  zinc finger matrin-type protein 3 isoform X2

      UniProtKB/Swiss-Prot
      O08781
      UniProtKB/TrEMBL
      A0A8I6GFU9, A6IHN5

    3. XM_063282483.1 → XP_063138553.1  zinc finger matrin-type protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GFU9, A0A8L2Q6J0

    4. XM_063282489.1 → XP_063138559.1  zinc finger matrin-type protein 3 isoform X2

      UniProtKB/Swiss-Prot
      O08781
      UniProtKB/TrEMBL
      A0A8I6GFU9, A6IHN5

    5. XM_063282486.1 → XP_063138556.1  zinc finger matrin-type protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GFU9, A0A8L2Q6J0

    6. XM_063282488.1 → XP_063138558.1  zinc finger matrin-type protein 3 isoform X2

      UniProtKB/Swiss-Prot
      O08781
      UniProtKB/TrEMBL
      A0A8I6GFU9, A6IHN5

    7. XM_063282484.1 → XP_063138554.1  zinc finger matrin-type protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GFU9, A0A8L2Q6J0

    8. XM_063282487.1 → XP_063138557.1  zinc finger matrin-type protein 3 isoform X2

      UniProtKB/Swiss-Prot
      O08781
      UniProtKB/TrEMBL
      A0A8I6GFU9, A6IHN5

    9. XM_063282490.1 → XP_063138560.1  zinc finger matrin-type protein 3 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08781.1 GenPept UniProtKB/Swiss-Prot:O08781

    Gene LinkOut

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