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    EMC6 Emc6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EMC6
    Official Full Name
    Emc6p
    Primary source
    SGD:S000003937
    Locus tag
    YLL014W
    See related
    AllianceGenome:SGD:S000003937; FungiDB:YLL014W; VEuPathDB:YLL014W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein folding in endoplasmic reticulum. Located in endoplasmic reticulum. Part of EMC complex. Orthologous to human EMC6 (ER membrane protein complex subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EMC6 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (121322..121648)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ATP-binding cassette bilirubin transporter BPT1 Neighboring gene mRNA-binding protein PUF3 Neighboring gene sterol esterase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ER membrane complex (EMC) can functionally replace the Oxa1 insertase in mitochondria. Güngör B, et al. PLoS Biol, 2022 Mar. PMID 35231030, Free PMC Article
    2. Structure of the ER membrane complex, a transmembrane-domain insertase. Bai L, et al. Nature, 2020 Aug. PMID 32494008, Free PMC Article
    3. Evidence for interaction between Hsp90 and the ER membrane complex. Kudze T, et al. Cell Stress Chaperones, 2018 Sep. PMID 29808299, Free PMC Article
    4. Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Richard M, et al. Proc Natl Acad Sci U S A, 2013 Mar 12. PMID 23431131, Free PMC Article
    5. Pre-emptive Quality Control of a Misfolded Membrane Protein by Ribosome-Driven Effects. Lakshminarayan R, et al. Curr Biol, 2020 Mar 9. PMID 31956032, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding in endoplasmic reticulum HGI PubMed 
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of EMC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Emc6p
    NP_013087.1
    • Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      121322..121648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181834.1 → NP_013087.1  TPA: Emc6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013087.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXY8, Q12431
      UniProtKB/TrEMBL
      A7A0P2, B3LTF4, C8ZCV9, G2WII1, N1NYU6
      Conserved Domains (1) summary
      pfam07019
      Location:24 → 101
      Rab5ip; Rab5-interacting protein (Rab5ip)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12431.1

    Gene LinkOut

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