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    DPP3 dipeptidyl peptidase 3 [ Homo sapiens (human) ]

    Gene ID: 10072, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DPP3provided by HGNC
    Official Full Name
    dipeptidyl peptidase 3provided by HGNC
    Primary source
    HGNC:HGNC:3008
    See related
    Ensembl:ENSG00000254986 MIM:606818; AllianceGenome:HGNC:3008
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPPIII
    Summary
    This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
    Expression
    Ubiquitous expression in colon (RPKM 13.2), appendix (RPKM 10.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DPP3 in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (66480434..66509657)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (66476691..66505896)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66247905..66277128)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 5 open reading frame 63 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66232341-66232842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66232843-66233342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3593 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3594 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66243741-66244561 Neighboring gene pellino E3 ubiquitin protein ligase family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66245199-66245792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66246731-66247298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5045 Neighboring gene DPP3 divergent transcript Neighboring gene skeletal muscle cis-regulatory module in DPP3 intron Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66258390-66259340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5046 Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene zinc finger DHHC-type containing 24 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66298267-66298846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66298847-66299424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66307071-66307841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5049 Neighboring gene Sharpr-MPRA regulatory region 1034 Neighboring gene actinin alpha 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tumor cytosol dipeptidyl peptidase III activity is increased with histological aggressiveness of ovarian primary carcinomas. Simaga S, et al. Gynecol Oncol, 2003 Oct. PMID 14529681
    2. Aprotinin interacts with substrate-binding site of human dipeptidyl peptidase III. Agić D, et al. J Biomol Struct Dyn, 2019 Sep. PMID 30198396
    3. Identification of dipeptidyl peptidase 3 as the Angiotensin-(1-7) degrading peptidase in human HK-2 renal epithelial cells. Cruz-Diaz N, et al. Peptides, 2016 Sep. PMID 27315786, Free PMC Article
    4. Human dipeptidyl peptidase III mRNA variant I and II are expressed concurrently in multiple tumor derived cell lines and translated at comparable efficiency in vitro. Prajapati SC, et al. Mol Biol Rep, 2016 Jun. PMID 27153830
    5. Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition. Kumar P, et al. Sci Rep, 2016 Mar 30. PMID 27025154, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Dipeptidyl peptidase 3 (DPP3) inhibits immune escape of gastric cancer cells through down-regulation of major histocompatibility complex class I chain-related gene B (MICB) expression].
      Title: [Dipeptidyl peptidase 3 (DPP3) inhibits immune escape of gastric cancer cells through down-regulation of major histocompatibility complex class I chain-related gene B (MICB) expression].
    2. DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis.
      Title: DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis.
    3. Dipeptidyl-peptidase 3 and IL-6: potential biomarkers for diagnostics in COVID-19 and association with pulmonary infiltrates.
      Title: Dipeptidyl-peptidase 3 and IL-6: potential biomarkers for diagnostics in COVID-19 and association with pulmonary infiltrates.
    4. Involvement of DPP3 in modulating oncological features and oxidative stress response in esophageal squamous cell carcinoma.
      Title: Involvement of DPP3 in modulating oncological features and oxidative stress response in esophageal squamous cell carcinoma.
    5. Identification of an Additional Metal-Binding Site in Human Dipeptidyl Peptidase III.
      Title: Identification of an Additional Metal-Binding Site in Human Dipeptidyl Peptidase III.
    6. The emerging role of dipeptidyl peptidase 3 in pathophysiology.
      Title: The emerging role of dipeptidyl peptidase 3 in pathophysiology.
    7. A Novel Indicator of Myocardial Injury after Acute Myocardial Infarction: 'DPP-3'.
      Title: A Novel Indicator of Myocardial Injury after Acute Myocardial Infarction: 'DPP-3'.
    8. DPP3 expression promotes cell proliferation and migration in vitro and tumour growth in vivo, which is associated with poor prognosis of oesophageal carcinoma.
      Title: DPP3 expression promotes cell proliferation and migration in vitro and tumour growth in vivo, which is associated with poor prognosis of oesophageal carcinoma.
    9. Dipeptidyl Peptidase 3 Activity as a Promising Biomarker of Bone Fragility in Postmenopausal Women.
      Title: Dipeptidyl Peptidase 3 Activity as a Promising Biomarker of Bone Fragility in Postmenopausal Women.
    10. DPP3/CDK1 contributes to the progression of colorectal cancer through regulating cell proliferation, cell apoptosis, and cell migration.
      Title: DPP3/CDK1 contributes to the progression of colorectal cancer through regulating cell proliferation, cell apoptosis, and cell migration.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11387, FLJ22331

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloexopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    dipeptidyl peptidase 3
    Names
    DPP III
    dipeptidyl aminopeptidase III
    dipeptidyl arylamidase III
    dipeptidyl peptidase III
    enkephalinase B
    NP_001243599.1
    NP_005691.2
    NP_569710.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032068.1 RefSeqGene

      Range
      5026..34249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256670.2 → NP_001243599.1  dipeptidyl peptidase 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AJ271216, AK297199, AK315478, DC407885
      Consensus CDS
      CCDS58147.1
      UniProtKB/TrEMBL
      Q5JPB8
      Related
      ENSP00000436941.1, ENST00000530165.5
      Conserved Domains (1) summary
      pfam03571
      Location:117 → 674
      Peptidase_M49; Peptidase family M49

    2. NM_005700.5 → NP_005691.2  dipeptidyl peptidase 3 isoform 1

      See identical proteins and their annotated locations for NP_005691.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AJ271216, AK315478, DC407885
      Consensus CDS
      CCDS8141.1
      UniProtKB/Swiss-Prot
      B2RDB5, B4DLX4, F5H8L6, O95748, Q969H2, Q9BV67, Q9HAL6, Q9NY33
      UniProtKB/TrEMBL
      Q5JPB8
      Related
      ENSP00000435284.1, ENST00000532677.5
      Conserved Domains (1) summary
      pfam03571
      Location:147 → 704
      Peptidase_M49; Peptidase family M49

    3. NM_130443.4 → NP_569710.2  dipeptidyl peptidase 3 isoform 1

      See identical proteins and their annotated locations for NP_569710.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate acceptor splice site at a 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AL833475, BC024271, CD366941, DC407885
      Consensus CDS
      CCDS8141.1
      UniProtKB/Swiss-Prot
      B2RDB5, B4DLX4, F5H8L6, O95748, Q969H2, Q9BV67, Q9HAL6, Q9NY33
      UniProtKB/TrEMBL
      Q5JPB8
      Related
      ENSP00000432782.2, ENST00000531863.6
      Conserved Domains (1) summary
      pfam03571
      Location:147 → 704
      Peptidase_M49; Peptidase family M49

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      66480434..66509657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      66476691..66505896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NY33.2 GenPept UniProtKB/Swiss-Prot:Q9NY33

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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