SPL2 Spl2p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SPL2
Official Full Name: Spl2p
Primary source: SGD:S000001178
Locus tag: YHR136C
See related: AllianceGenome:SGD:S000001178; FungiDB:YHR136C; VEuPathDB:YHR136C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in protein targeting to vacuole. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Cell-to-cell heterogeneity of phosphate gene expression in yeast is controlled by alternative transcription, 14-3-3 and Spl2.
Title: Cell-to-cell heterogeneity of phosphate gene expression in yeast is controlled by alternative transcription, 14-3-3 and Spl2.
Lack of 14-3-3 proteins in Saccharomyces cerevisiae results in cell-to-cell heterogeneity in the expression of Pho4-regulated genes SPL2 and PHO84
Title: Lack of 14-3-3 proteins in Saccharomyces cerevisiae results in cell-to-cell heterogeneity in the expression of Pho4-regulated genes SPL2 and PHO84.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

NP_012004.1

Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation by targeting Pho87p to the vacuole; upstream region harbors putative hypoxia response element (HRE) cluster; overproduction suppresses a plc1 null mutation; promoter shows an increase in Snf2p occupancy after heat shock; GFP-fusion protein localizes to the cytoplasm