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    CHS7 Chs7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856545, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CHS7
    Official Full Name
    Chs7p
    Primary source
    SGD:S000001184
    Locus tag
    YHR142W
    See related
    AllianceGenome:SGD:S000001184; FungiDB:YHR142W; VEuPathDB:YHR142W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables unfolded protein binding activity. Involved in chitin biosynthetic process; endoplasmic reticulum to Golgi vesicle-mediated transport; and protein folding. Located in cellular bud neck and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CHS7 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (383538..384488)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribosomal 60S subunit protein L42B Neighboring gene Dse2p Neighboring gene DNA-directed RNA polymerase core subunit RPC10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Candida albicans strains deficient in CHS7, a key regulator of chitin synthase III, exhibit morphogenetic alterations and attenuated virulence. Sanz M, et al. Microbiology (Reading), 2005 Aug. PMID 16079341
    2. Multiple quality control mechanisms monitor yeast chitin synthase folding in the endoplasmic reticulum. Sanchez N, et al. Mol Biol Cell, 2023 Dec 1. PMID 37819693, Free PMC Article
    3. Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis in Saccharomyces cerevisiae. Trilla JA, et al. J Cell Biol, 1999 Jun 14. PMID 10366589, Free PMC Article
    4. The chaperone Chs7 forms a stable complex with Chs3 and promotes its activity at the cell surface. Dharwada ST, et al. Traffic, 2018 Apr. PMID 29405545
    5. Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER. Kota J, et al. J Cell Biol, 2005 Jan 3. PMID 15623581, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in prospore membrane HDA PubMed 

    General protein information

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    Preferred Names
    Chs7p
    NP_012011.1
    • hypothetical protein; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      383538..384488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179272.1 → NP_012011.1  TPA: Chs7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012011.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL91, P38843
      UniProtKB/TrEMBL
      A6ZT50, B3LSQ6, C7GXW2, C8Z9T9, G2WFL5, N1P9G2
      Conserved Domains (1) summary
      pfam12271
      Location:2 → 299
      Chs3p; Chitin synthase III catalytic subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38843.1

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